{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:23:34Z","timestamp":1791437014978,"version":"4.3.3"},"posted":{"date-parts":[[2026,2,27]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":101,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Mild Behavioural Impairment (MBI) is defined by later-life onset of persistent behavioural changes and is recognized as a risk marker for cognitive decline and dementia. Apathy, a core MBI domain characterized by diminished interest, initiative, and emotional reactivity, can emerge before dementia and is hypothesized to be associated with structural brain changes.<\/jats:p>\n                <jats:p>While previous studies have explored Alzheimer disease (AD)-related neuroanatomical substrates of apathy in the dementia clinical stage, few have investigated these associations in cognitively normal (CN) or mild cognitive impairment (MCI) individuals with persistent apathy consistent with MBI. Thus, this study explores structural brain differences between individuals with MBI-apathy and those without neuropsychiatric symptoms (no-NPS).<\/jats:p>\n                <jats:p>Participants (n = 446; mean age = 69.6 years; 79.8% CN; 62.8% female) were drawn from the National Alzheimer\u2019s Coordinating Center and categorized into MBI-apathy (n = 59) and no-NPS (n = 387) groups. Linear regressions were used to model associations between NPS group and regional brain measures, with adjustments for age, sex, years of education, apolipoprotein E4 carrier status, intracranial volume, and Mini-Mental State Examination score, with false discovery rate (FDR) correction for multiple comparisons. Primary outcomes included two predefined AD meta-regions-of-interest (ROIs): 1) thickness: a composite measure of mean cortical thickness across the entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, inferior parietal lobule, fusiform gyrus, and precuneus; and 2) volume: a composite measure of mean cortical and subcortical grey matter volume across the hippocampus, entorhinal cortex, amygdala, middle temporal gyrus, inferior parietal lobule, and precuneus. Primary outcomes also included cortical thickness and grey matter volume among individual ROIs including the ventral striatum (VS), anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), ventrolateral prefrontal cortex (vlPFC), and dorsolateral prefrontal cortex (dlPFC).<\/jats:p>\n                <jats:p>\n                  MBI-apathy status was associated with significantly lower AD-meta-ROI cortical thickness (\n                  <jats:italic>Z<\/jats:italic>\n                  -score difference [95% CI]; FDR-corrected\n                  <jats:italic>p<\/jats:italic>\n                  -value, -0.43 [-0.73 \u2013 [-0.12]]; 0.025) and lower AD meta-ROI grey matter volume (-0.50 [-0.71 \u2013 [-0.30]]; &lt;0.001). MBI-apathy was also associated with significantly lower dlPFC thickness (-0.40, [-0.70 \u2013 [-0.09]]; 0.02) and volume (-0.28 [-0.50\u2013 [-0.06]]; 0.026) and lower OFC volume (-0.32, [-0.57 \u2013 [-0.07]]; 0.026) compared to the no-NPS group.\n                <\/jats:p>\n                <jats:p>Within a non-dementia sample, MBI-apathy was more strongly associated with established AD-vulnerable regions than with regions that have been traditionally implicated in apathy in dementia. Results suggests that during CN and MCI stages, MBI-apathy may reflect early AD-related neurodegeneration, with conventional apathy-related structural changes becoming more prominent as disease progresses.<\/jats:p>","DOI":"10.64898\/2026.02.25.26347107","type":"posted-content","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:55:10Z","timestamp":1772236510000},"source":"Crossref","is-referenced-by-count":1,"title":["Apathy in Mild Behavioural Impairment: Associations with Cortical Thickness and Grey Matter Volume"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-7245","authenticated-orcid":false,"given":"Daniella","family":"Vellone","sequence":"first","affiliation":[{"name":"Faculty of Graduate Studies, University of Calgary, Calgary, Alberta T2N 1N4, Canada"},{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, 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Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"O\u2019Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-3224","authenticated-orcid":false,"given":"Nils D.","family":"Forkert","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Calgary, Alberta T3B 6A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-1668","authenticated-orcid":false,"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-3731","authenticated-orcid":false,"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"},{"name":"Mathison Centre for Mental Health Research and 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