{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:35:45Z","timestamp":1783020945749,"version":"3.54.6"},"posted":{"date-parts":[[2026,3,4]]},"group-title":"Epidemiology","reference-count":23,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Early adulthood alcohol use may influence later life memory, but few studies assessed this association. Synthesizing two cohorts, we estimated effects of prospectively reported early life alcohol use on memory across middle and later adulthood.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We used National Longitudinal Study of Youth 1979 (NLSY79, n=12221, alcohol reports ages 18-26), Health and Retirement Study (HRS, age 50-56 at enrollment, n=21,263), and a synthetic cohort matching early life alcohol use among NLSY79 participants to later life memory among HRS participants. Covariate-adjusted linear mixed models regressed memory (word list recall) on alcohol use category (none, light\/moderate, heavy).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Early adulthood alcohol use category was not associated with midlife memory in the NLSY79 cohort or with middle to late life memory or memory change in the synthetic cohort.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>Early adulthood alcohol use has little association with memory function at midlife or later.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.02.27.26346914","type":"posted-content","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:30:23Z","timestamp":1772681423000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations of alcohol use in early and middle adulthood with mid- and late-life cognition - a synthetic cohort approach"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-6009","authenticated-orcid":false,"given":"Peter T","family":"Buto","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-032X","authenticated-orcid":false,"given":"Katrina","family":"Kezios","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Zeki Al Hazzouri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University Mailman School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-3081","authenticated-orcid":false,"given":"M Maria","family":"Glymour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026070211251151000_2026.02.27.26346914v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"2026070211251151000_2026.02.27.26346914v2.2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00713"},{"key":"2026070211251151000_2026.02.27.26346914v2.3","doi-asserted-by":"publisher","DOI":"10.1111\/imj.70288"},{"key":"2026070211251151000_2026.02.27.26346914v2.4","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0273-z"},{"key":"2026070211251151000_2026.02.27.26346914v2.5","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S198772"},{"key":"2026070211251151000_2026.02.27.26346914v2.6","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy133"},{"key":"2026070211251151000_2026.02.27.26346914v2.7","doi-asserted-by":"publisher","DOI":"10.1093\/workar\/wax032"},{"key":"2026070211251151000_2026.02.27.26346914v2.8","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001761"},{"key":"2026070211251151000_2026.02.27.26346914v2.9","unstructured":"SAMHSA, Center for Behavioral Health Statistics and Quality. 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