{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:05:09Z","timestamp":1772705109677,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,2]]},"group-title":"Pathology","reference-count":48,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Placental growth and function are imperative for healthy fetal growth; data on placentas can inform research and clinical care. Measuring placental size after delivery should be easy, but current methods are hard to standardize and error prone. We developed PlacentaVision using artificial intelligence (AI)-based models, to automatically, accurately, and precisely measure placentas from digital photographs.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to compare placental disc morphology between gross pathology examination (human measurements) and our automated PlacentaVision model (AI measurements).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PlacentaVision is a multi-site study to assess placental morphology, features, and pathologies from digital photographs. We built a large dataset of digital placenta photographs and clinical data from singleton births at three large hospitals: Northwestern Memorial (Chicago; n=24,933), UPMC Magee-Womens (Pittsburgh; n=1198) and Mbarara Regional Referral (Uganda, n=1715). Data and images were from the medical record for Northwestern, part of a biobank study for Magee, and from our prospective studies for Mbarara. We compared long and short disc axis length (defined by Amsterdam criteria) between human and AI-based PlacentaVision measurements by calculating the difference and using Bland-Altman; we stratified by site, disc shape, infant sex, and term\/preterm birth.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean (SD) disc length was 19.2 (3.1) and 18.6 (3.1) cm from PlacentaVision and human measurement, respectively, with a difference of 0.57 (2.19) cm. Disc width was 16.3 (2.3) cm and 16.1 (2.4) cm from PlacentaVision and human measurement, respectively, with a difference of 0.25 (1.85) cm. Bland-Altman limits of agreement were \u22123.7 to 4.9 cm for length and \u22123.4 to 3.9 cm for width. Irregularly-shaped placentas had a greater difference between PlacentaVision and human measurements compared to those with round\/oval shapes (length differences of 1.53 and 0.45 cm respectively). Further, there were length differences by site (Northwestern 0.6, Magee 0.0, and Mbarara 0.4) and gestational age at birth (preterm 0.71, term 0.53 cm), but similar results for male and female placentas. Results for width were similar to length.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AI-based measurements were less than a cm from human measurements overall. Our findings of larger differences for irregular shapes and preterm may indicate it is difficult for humans to measure irregular or small placentas according to protocol. PlacentaVision can automate and standardize the process.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.02.28.26347346","type":"posted-content","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:35:20Z","timestamp":1772494520000},"source":"Crossref","is-referenced-by-count":0,"title":["Applying AI models to digital placental photographs to automate and improve morphology assessments"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-7785","authenticated-orcid":false,"given":"Alison D","family":"Gernand","sequence":"first","affiliation":[{"name":"The Pennsylvania State University, Department of Nutritional Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E","family":"Walker","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, Department of Nutritional Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimu","family":"Pan","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, College of Information Sciences and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manas","family":"Mehta","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, College of Information Sciences and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Sincerbeaux","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, Department of Nutritional Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, College of Nursing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Bebell","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Medical Practice Evaluation Center, Center for Global Health, and Department of Medicine, Infectious Diseases Division; Harvard Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ngonzi","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology Department of Obstetrics and Gynaecology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet M.","family":"Catov","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren B.","family":"Skvarca","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Z","family":"Wang","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University, College of Information Sciences and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-057X","authenticated-orcid":false,"given":"Jeffery A","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Northwestern Memorial Hospital, Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026030501100568000_2026.02.28.26347346v1.1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12688\/gatesopenres.13215.1","article-title":"How often is the placenta included in human pregnancy research? 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