{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:39:07Z","timestamp":1772793547237,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,3]]},"group-title":"Sports Medicine","reference-count":53,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  We examined whether a 24-week resistance training program influenced brain amyloid-\u03b2 (A\u03b2) and Alzheimer\u2019s Disease (AD)-related blood-based biomarkers. Ninety cognitively normal, physically inactive older adults aged 65\u201380 years were randomly allocated to a 24-week resistance training program (three \u223c60-min supervised sessions\/week) or a wait-list control group. Primary analyses assessed exercise-induced changes in brain A\u03b2 (Centiloid values) and plasma ptau217\/A\u03b21-42 IPMS ratio. Secondary analyses examined ptau217\/A\u03b242 SIMOA ratio, ptau217, ptau181 and A\u03b242\/40, as well as potential interactions with sex, age, education, apolipoprotein \u03b54 (\n                  <jats:italic>APOE4<\/jats:italic>\n                  ) status, amyloid PET-positivity, and comorbidities. The intervention produced no significant differences on brain A\u03b2 or AD-related blood-based biomarkers (p&gt;0.05) compared to the control group. However, the ptau217\/A\u03b21\u201342 IPMS ratio showed a small, non-significant increase in the control group (SMD = 0.162; 95% CI: \u22120.159 to 0.483) while remaining stable in the exercise group (SMD = 0.01; 95% CI: \u22120.291 to 0.310) with a similar trend for ptau217\/A\u03b242 SIMOA. Moderator analyses indicated differential responses by amyloid PET-positivity and\n                  <jats:italic>APOE4<\/jats:italic>\n                  status on brain A\u03b2 (p for interaction&lt;0.05), with increases observed in\n                  <jats:italic>APOE4<\/jats:italic>\n                  carriers and amyloid PET\u2013positive individuals in the control group, whereas those allocated to the exercise intervention reduced their levels. The specificity observed within our subgroups suggests that resistance exercise may serve as a targeted intervention to modulate AD pathophysiology, raising new questions regarding its broader role in the delay of the disease in vulnerable populations.\n                <\/jats:p>","DOI":"10.64898\/2026.03.02.26347392","type":"posted-content","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:50:19Z","timestamp":1772581819000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of a 24-week resistance exercise program on brain amyloid and Alzheimer\u2019s disease blood-based biomarkers: the AGUEDA randomized controlled trial"],"prefix":"10.64898","author":[{"given":"Patricio","family":"Solis-Urra","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"},{"name":"Faculty of Education and Social Sciences, Universidad Andres Bello, Vi\u00f1a del Mar, Chile"},{"name":"Neuroscience, AdventHealth Research Institute, Orlando, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-1647","authenticated-orcid":false,"given":"Marcos","family":"Olvera-Rojas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Garc\u00eda-Rivero","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Universitario Virgen de Las Nieves, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Ibs. GRANADA, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Shekari","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Oberlin","sequence":"additional","affiliation":[{"name":"Neuroscience, AdventHealth Research Institute, Orlando, FL"},{"name":"Department of Psychiatry, Weill Cornell Medicine, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk I.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Neuroscience, AdventHealth Research Institute, Orlando, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-4358","authenticated-orcid":false,"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"G\u00f3mez-R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hospital Universitario Virgen de Las Nieves, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Ibs. 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