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Other cargos, such as peroxisomes and mRNAs, \u201chitchhike\u201d on early endosomes to move throughout the long hyphae of these organisms. In\n                  <jats:italic>Aspergillus nidulans<\/jats:italic>\n                  , peroxisomes hitchhike on early endosomes using the endosomal protein PxdA and the peroxisomal protein AcbdA. The HookA adaptor protein links endosomes to microtubule motors. Here, we set out to explore the physiological functions of peroxisome hitchhiking and endosome motility.\n                  <jats:italic>Aspergillus nidulans<\/jats:italic>\n                  has a complex life cycle that includes asexual and sexual reproduction.\n                  <jats:italic>A. nidulans<\/jats:italic>\n                  and other fungi within the Pezizomycotina subphylum are also notable for the vast number of secondary metabolites they produce. Light and other environmental conditions influence developmental decisions and secondary metabolite production. Here, we found that sexual reproduction is favored in the absence of endosome motility, even in the light, which normally promotes asexual reproduction. RNA sequencing of strains lacking PxdA-marked motile early endosomes showed altered expression of genes involved in development. Unexpectedly, we also observed altered expression of genes involved in secondary metabolism in strains lacking endosome motility and peroxisome hitchhiking. Using mass spectrometry, we found that the loss of endosome motility affected the biosynthesis of secondary metabolites, including sterigmatocystin, a carcinogenic mycotoxin that is a food contaminant. Finally, in a pathogenic species,\n                  <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                  , we found that deletion of its\n                  <jats:italic>pxdA<\/jats:italic>\n                  homolog also significantly altered secondary metabolite production. Our work uncovers an unexpected link between organelle motility, developmental decisions in response to light, and secondary metabolite production in filamentous fungi.\n                <\/jats:p>","DOI":"10.64898\/2026.03.03.708097","type":"posted-content","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:56:03Z","timestamp":1772700963000},"source":"Crossref","is-referenced-by-count":1,"title":["Endosome motility controls light-responsive reproductive development and secondary metabolite production in\n                  <i>Aspergillus<\/i>"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-1032","authenticated-orcid":false,"given":"Gaurav","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Weill Cornell Medicine, New York, NY"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-003X","authenticated-orcid":false,"given":"Jessica L.","family":"Allen","sequence":"additional","affiliation":[{"name":"Conservation Data and Science, NatureServe, Arlington, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-4224","authenticated-orcid":false,"given":"Livia D. S.","family":"Oster","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of Minnesota, Twin Cities, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-0154","authenticated-orcid":false,"given":"Mira Syahfriena","family":"Amir Rawa","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Immunology and Bacteriology, University of Wisconsin, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique A.","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Immunology and Bacteriology, University of Wisconsin, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-2749","authenticated-orcid":false,"given":"Jin Woo","family":"Bok","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & 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