{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:31:09Z","timestamp":1772951469352,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,5]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":15,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Syphilis remains a major public health concern. However, current serologic assays are limited in their ability to distinguish active from previously treated disease. We applied tandem mass tag-based quantitative proteomics to plasma from 10 adults with active syphilis and 10 age- and gender-matched non-diseased controls. We identified 54 differentially regulated proteins (36 upregulated, 18 downregulated). Those proteins map to immune and inflammatory responses, acute-phase signaling, coagulation and vascular pathways, and cellular stress processes. Three sets of between 2-5 proteins achieved\n                  <jats:underline>&gt;<\/jats:underline>\n                  99% discrimination between cases and controls. Our exploratory findings support proteomics as a potential tool to develop novel syphilis diagnostics.\n                <\/jats:p>","DOI":"10.64898\/2026.03.04.26347505","type":"posted-content","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:25:19Z","timestamp":1772749519000},"source":"Crossref","is-referenced-by-count":0,"title":["An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Active Syphilis in Adults"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-7842","authenticated-orcid":false,"given":"Cody","family":"Chou","sequence":"first","affiliation":[{"name":"Harvard University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shad R.","family":"Morton","sequence":"additional","affiliation":[{"name":"Wyss Institute, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelika A","family":"Konda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silver","family":"Vargas","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Reyes-Diaz","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos F.","family":"Caceres","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Medicine and Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trey","family":"Toombs","sequence":"additional","affiliation":[{"name":"Wyss Institute, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushdy","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Wyss Institute, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lao-Tzu","family":"Allan-Blitz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026030710100801000_2026.03.04.26347505v1.1","unstructured":"WHO. Sexually Transmitted Infections (STIs). World Health Organization. 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