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We introduce a Hodge-Laplacian topological framework that localizes higher-order \u201cloop\u201d (1-cycle) organization within functional connectome, maps each loop to specific edges and networks, and yields a subject-level measure of loop expression. Applied to resting-state fMRI from the ENIGMA-OCD consortium (1,024 patients and 1,028 controls across 28 sites), the framework identified 93 loop-level abnormalities in obsessive\u2013compulsive disorder (OCD), concentrated in frontoparietal and somatomotor systems. The edges forming these loops largely showed no significant differences between groups, indicating that the abnormalities were invisible to conventional FC analysis. The frontoparietal and somatomotor loop clusters recurred across the clinical subgroups, suggesting convergence on a shared higher-order phenotype. 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These results indicate that coordinated, multi-edge pathology exists and can be localized even when pairwise analyses fail to detect it, positioning higher-order topology as a generalizable axis for mapping circuit pathology across psychiatric and neurological disorders.<\/jats:p>","DOI":"10.64898\/2026.03.04.709586","type":"posted-content","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:40:23Z","timestamp":1772858423000},"source":"Crossref","is-referenced-by-count":0,"title":["Mapping Higher-Order Topology in OCD Brain Networks with Hodge Laplacian"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-719X","authenticated-orcid":false,"given":"Hanyang","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany"},{"name":"School of Medicine and Health, TUM-NIC Neuroimaging Center, Technical University of 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