{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:46:46Z","timestamp":1791521206856,"version":"4.3.4"},"posted":{"date-parts":[[2026,3,7]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Understanding host susceptibility to\n                  <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                  (\n                  <jats:italic>Mtb)<\/jats:italic>\n                  is critical for the development of new vaccines. Certain individuals \u201cresist\u201d becoming infected with\n                  <jats:italic>Mtb<\/jats:italic>\n                  despite intensive exposure; however, it is unknown whether there is a genetic basis for \u201cresistance\u201d to\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection across populations. Here we conducted a genome-wide association study (GWAS) of resistance to\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection by carefully characterizing exposure to TB patients among 4,058 close contacts in India, Brazil, and South Africa. 476 (12%) \u201cresisters\u201d remained free of\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection despite substantial exposure to highly infectious TB patients. GWAS identified a novel chromosome 13 locus (rs1295104126) associated with resistance across the multi-ancestry meta-analysis. Comparing\n                  <jats:italic>Mtb<\/jats:italic>\n                  -infection to all uninfected contacts, irrespective of exposure, yielded a different locus on chromosome 6 (rs28752534), near the HLA-II region. These findings demonstrate a common genetic basis for resistance to\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection across multi-ancestral cohorts with potential to elucidate novel mechanisms of protection from\n                  <jats:italic>Mtb<\/jats:italic>\n                  infection.\n                <\/jats:p>","DOI":"10.64898\/2026.03.06.26347614","type":"posted-content","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:20:11Z","timestamp":1772893211000},"source":"Crossref","is-referenced-by-count":2,"title":["Novel Genetic Locus Associated with Resistance to\n                  <i>M. tuberculosis<\/i>\n                  Infection: A Multi-Ancestry Genome-Wide Association Study"],"prefix":"10.64898","author":[{"given":"Neel R.","family":"Gandhi","sequence":"first","affiliation":[{"name":"Emory University, Atlanta, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-8128","authenticated-orcid":false,"given":"Matheus","family":"Fernandes Gyorfy","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandar","family":"Paradkar","sequence":"additional","affiliation":[{"name":"Byramjee Jeejeebhoy Government Medical College - 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