{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:28:05Z","timestamp":1785414485977,"version":"3.56.0"},"posted":{"date-parts":[[2026,3,13]]},"group-title":"Cancer Biology","reference-count":42,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R01GM072562"],"award-info":[{"award-number":["R01GM072562"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01CA227789"],"award-info":[{"award-number":["R01CA227789"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006153","name":"Ladies Leukemia League","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100006153","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Ascites is a life-threatening complication of advanced malignancies, yet how tumors disrupt systemic fluid homeostasis remains poorly understood. Here, using a\n                  <jats:italic>Drosophila<\/jats:italic>\n                  tumor allograft model that recapitulates key features of cancer-associated ascites, we identify a tumor\u2013microbiome\u2013renal axis that controls host fluid balance. Tumor-bearing hosts develop severe abdominal fluid accumulation accompanied by marked expansion and systemic dissemination of the gut commensal\n                  <jats:italic>Acetobacter aceti<\/jats:italic>\n                  . Tumor-induced bacterial dissemination activates innate immune signaling in the Malpighian tubules, the insect renal tubules, leading to uric acid accumulation, nephrolithiasis, and progressive ascites. Selective elimination of\n                  <jats:italic>A. aceti<\/jats:italic>\n                  , or renal-tubule-specific suppression of IMD\/NF-\u03baB signaling, abolishes these pathological changes. Conversely, mono-association of axenic hosts with\n                  <jats:italic>A. aceti<\/jats:italic>\n                  is sufficient to recapitulate the ascites phenotype through IMD pathway activation. Together, these findings demonstrate that tumors can remotely induce nephrogenic pathology through species-specific microbiome-dependent immune activation, establishing a mechanistic link between cancer progression and systemic fluid imbalance.\n                <\/jats:p>","DOI":"10.64898\/2026.03.10.710910","type":"posted-content","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:40:37Z","timestamp":1773441637000},"source":"Crossref","is-referenced-by-count":0,"title":["Tumor-induced species-specific dysbiosis drives renal innate immunity and nephrogenic ascites"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-3424","authenticated-orcid":false,"given":"Anindita","family":"Barua","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1362-4755","authenticated-orcid":false,"given":"Fei","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9445-3978","authenticated-orcid":false,"given":"Hongcun","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-9769","authenticated-orcid":false,"given":"Wu-Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026032300500805000_2026.03.10.710910v2.1","unstructured":"Goosenberg E , Kudaravalli P , Samant H . 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