{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:21:18Z","timestamp":1785410478038,"version":"3.56.0"},"posted":{"date-parts":[[2026,3,13]]},"group-title":"Neuroscience","reference-count":64,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"National Institute of Mental Health","award":["R01 MH123473"],"award-info":[{"award-number":["R01 MH123473"]}]},{"name":"National Institute of Mental Health","award":["R01 MH126911"],"award-info":[{"award-number":["R01 MH126911"]}]},{"name":"National Institute of Mental Health","award":["F31 MH140552"],"award-info":[{"award-number":["F31 MH140552"]}]},{"award":["R01 AG083919"],"award-info":[{"award-number":["R01 AG083919"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National Institute of Biomedical Imaging and Bioengineering","award":["R01 EB027119"],"award-info":[{"award-number":["R01 EB027119"]}]},{"name":"U.S. National Science Foundation","award":["AST-2421845"],"award-info":[{"award-number":["AST-2421845"]}]},{"name":"U.S. National Science Foundation","award":["DGE-2234667"],"award-info":[{"award-number":["DGE-2234667"]}]},{"name":"Simons Foundation","award":["MPS-AI-00010513"],"award-info":[{"award-number":["MPS-AI-00010513"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,29]]},"abstract":"<jats:p>Background: To understand the neurobiology underlying psychopathology, we need valid measurements of brain function. Group atlases for brain functional connectivity (FC) allow for efficient comparisons, but they fail to account for inter-individual variability in network topography, a problem that personalized methods address. We assess the validity and predictive utility of group and personalized approaches of quantifying FC by 1) comparing effect sizes of associations with clinical metrics; and 2) accounting for spatial features of brain networks when examining the association between FC and clinical metrics. Methods: 324 teens ages 13-16 participated. Personalized networks were estimated using a hierarchical Bayesian model. Effect size comparisons were done by comparing the correlations between FC and clinical metrics (depression, ruminative coping style, and sensitivity to punishment\/reward) with Steigler's Z-test. We also conducted regressions, with clinical metrics as the dependent variables. Those models included FC and spatial features, together and alone. Results: The effect size comparisons did not survive FDR correction. However, exploratory permutation tests show that 1) the magnitude of the correlations with depression are larger on average for the intersection estimates of FC than the group estimates; and 2) the magnitude of the correlations with a ruminative coping style are larger on average for the intersection estimates of FC than the personalized estimate. The other comparisons conducted using permutation tests are not significant. Multiple regression analyses demonstrated that only spatial features of networks, not FC, are associated with sensitivity to reward. Discussion: These results imply that the intersection estimates are more valid than the group estimates, and that the intersection estimates have greater predictive utility than personalized estimates. Further, spatial features of functions networks may be useful in and of themselves in certain contexts. Therefore, researchers in psychiatry should take into consideration functional network topography in order to gain a better understanding of the neurobiology underlying psychopathology.<\/jats:p>","DOI":"10.64898\/2026.03.10.710919","type":"posted-content","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:40:33Z","timestamp":1773441633000},"source":"Crossref","is-referenced-by-count":0,"title":["Utility and validity of group atlas versus personalized functional network approaches for depressive constructs"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-6444","authenticated-orcid":false,"given":"Ellyn R","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Psychology, Northwestern University, Evanston, IL 60208;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B","family":"Alloy","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience, Temple University, 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