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Human genetic variation associated with transcript abundance (eQTLs) can help to advance our understanding, yet prior work has focused on profiling immune cell populations collected from peripheral blood primarily in adult populations, leaving uncharacterized tissue-resident lymphocytes collected from children. Here, we paired genotyping with gene expression profiling across four populations of tonsil-derived immune cell types \u2013 including previously uncharacterized germinal center B cells \u2013 collected from 103 children across development (ages 1-18). Using these data, we report cell-type specific gene networks and identify 13,393 eGenes (1,793 eGenes not previously reported in similar datasets) influenced by 27,603 eQTLs (5,199 not previously reported). We link discovered eQTLs to associations identified in pediatric and adult asthma and atopy traits, nominating 78 eGenes like\n                  <jats:italic>TRAF3<\/jats:italic>\n                  ,\n                  <jats:italic>ZBTB10<\/jats:italic>\n                  and\n                  <jats:italic>JAZF1<\/jats:italic>\n                  in disease relevant cell types. Our resource is freely available and exemplifies the importance of discovery in native tissues and across human development.\n                <\/jats:p>","DOI":"10.64898\/2026.03.13.711667","type":"posted-content","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:30:12Z","timestamp":1773779412000},"source":"Crossref","is-referenced-by-count":0,"title":["Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseases"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-2942","authenticated-orcid":false,"given":"Kim","family":"Lorenz","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-1660","authenticated-orcid":false,"given":"Samuel","family":"Yoon","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9228-5896","authenticated-orcid":false,"given":"Carole","family":"Le Coz","sequence":"additional","affiliation":[{"name":"Toulouse Institute for Infectious and Inflammatory Diseases, Universit\u00e9 de Toulouse, INSERM, CNRS, Infinity, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-6559","authenticated-orcid":false,"given":"Karen","family":"Zur","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Otorhinolaryngology: Head & Neck Surgery, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-2145","authenticated-orcid":false,"given":"Andrew","family":"Wells","sequence":"additional","affiliation":[{"name":"Center for Spatial and Functional Genomics, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Pathology, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-5318","authenticated-orcid":false,"given":"Neil","family":"Romberg","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-9994","authenticated-orcid":false,"given":"Benjamin F.","family":"Voight","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA"},{"name":"Corporal Michael J. 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