{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:07:46Z","timestamp":1790208466986,"version":"4.1.0"},"posted":{"date-parts":[[2026,3,17]]},"group-title":"Cancer Biology","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["P50 CA257881"],"award-info":[{"award-number":["P50 CA257881"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K12 CA184746"],"award-info":[{"award-number":["K12 CA184746"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/0184qbg02","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011619","name":"Society for Immunotherapy of Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Pancreatic cancer (PC) is broadly resistant to immune checkpoint blockade, although a subset of homologous recombination-deficient (HRD) tumors exhibits durable immune engagement. The genomic features that distinguish these immune-responsive tumors from immune-inert HRD tumors remain poorly understood. Here we identify a microhomology-mediated end joining (MMEJ) repair scar, the MMEJ Deletion Footprint (MDF), as a genomic readout of POLQ-associated error-prone repair that enriches for frameshift indels. Across the multi-omic discovery cohort integrating tumor genomics, single-nucleus transcriptomics and spatial immune profiling, MDF-high HRD PC exhibited increased frameshift-indel-derived neoantigens and interferon programs. MDF was further associated with remodeling of the myeloid compartment toward MHC II-high dendritic cell-like antigen-presenting macrophage states and the immune synapse architecture marked by increased spatial interaction between APC-like macrophages and cytotoxic CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells. These tissue-level features aligned with a functional trajectory shift of CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells, consistent with effective anti-tumor immunity and was associated with favorable clinical outcomes of patients. Together, our findings position MMEJ-linked repair scarring as actionable biology that connects an HRD genotype to immune organization and suggests rational immunotherapy combinations that may enhance antigen presentation and myeloid activation to extend durable benefit in HRD-lineage cancers.\n                <\/jats:p>","DOI":"10.64898\/2026.03.15.711961","type":"posted-content","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:50:13Z","timestamp":1773773413000},"source":"Crossref","is-referenced-by-count":3,"title":["POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-3102","authenticated-orcid":false,"given":"Wungki","family":"Park","sequence":"first","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Parker Institute for Cancer Immunotherapy, San Francisco, USA"},{"name":"Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-1515","authenticated-orcid":false,"given":"Shigeaki","family":"Umeda","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-6740","authenticated-orcid":false,"given":"Marc","family":"Hilmi","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Institut Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-9149","authenticated-orcid":false,"given":"Catherine","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Single-cell Analytics Innovation Lab, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6129-1254","authenticated-orcid":false,"given":"Nuray","family":"Tezcan","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-9491","authenticated-orcid":false,"given":"Haochen","family":"Zhang","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9467-8899","authenticated-orcid":false,"given":"Carly","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0158-6774","authenticated-orcid":false,"given":"Amin","family":"Yaqubie","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-0885","authenticated-orcid":false,"given":"Anna","family":"Varghese","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-017X","authenticated-orcid":false,"given":"Kevin","family":"Soares","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-753X","authenticated-orcid":false,"given":"Vaia","family":"Florou","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daewon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of gastrointestinal oncology, Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-130X","authenticated-orcid":false,"given":"Steven","family":"Maron","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-7108","authenticated-orcid":false,"given":"Guillem A.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4703-1560","authenticated-orcid":false,"given":"Fiyinfolu","family":"Balogun","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-2433","authenticated-orcid":false,"given":"Caitlin","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-3529","authenticated-orcid":false,"given":"Daehee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-2672","authenticated-orcid":false,"given":"Kenneth H.","family":"Yu","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-2022","authenticated-orcid":false,"given":"Joanne F.","family":"Chou","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-8127","authenticated-orcid":false,"given":"Akimasa","family":"Hayashi","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Pathology, Kyorin University School of Medicine, Mitaka-City, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-2090","authenticated-orcid":false,"given":"Fergus","family":"Keane","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4688-0958","authenticated-orcid":false,"given":"Danny","family":"Khalil","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-218X","authenticated-orcid":false,"given":"Walid K","family":"Chatila","sequence":"additional","affiliation":[{"name":"Marie-Jos\u00c8e and Henry R. Kravis Center for Molecular Oncology"},{"name":"Computational Oncology, Department of Epidemiology and Biostatistics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-3193","authenticated-orcid":false,"given":"Marinela","family":"Capanu","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-3291","authenticated-orcid":false,"given":"Ronan","family":"Chaligne","sequence":"additional","affiliation":[{"name":"Single-cell Analytics Innovation Lab, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-9041","authenticated-orcid":false,"given":"Michael J","family":"Pishvaian","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1108-4919","authenticated-orcid":false,"given":"Chaitanya","family":"Bandlamudi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Marie-Jos\u00c8e and Henry R. Kravis Center for Molecular Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-1407","authenticated-orcid":false,"given":"Nicolas","family":"Lecomte","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-5000","authenticated-orcid":false,"given":"Michael","family":"Berger","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Marie-Jos\u00c8e and Henry R. Kravis Center for Molecular Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-1366","authenticated-orcid":false,"given":"Olca","family":"Basturk","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-223X","authenticated-orcid":false,"given":"Vinod","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Parker Institute for Cancer Immunotherapy, San Francisco, USA"},{"name":"Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-8817","authenticated-orcid":false,"given":"Dana","family":"Pe\u2019er","sequence":"additional","affiliation":[{"name":"Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-4827","authenticated-orcid":false,"given":"Benoit","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-8793","authenticated-orcid":false,"given":"Benjamin","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"The Olayan Center for Cancer Vaccines, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-8535","authenticated-orcid":false,"given":"Agnel","family":"Sfeir","sequence":"additional","affiliation":[{"name":"Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-3023","authenticated-orcid":false,"given":"Christine","family":"Iacobuzio-Donahue","sequence":"additional","affiliation":[{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9873-5862","authenticated-orcid":false,"given":"Nadeem","family":"Riaz","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"},{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-9199","authenticated-orcid":false,"given":"Eileen M.","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"David M. Rubenstein Center for Pancreas Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026031908050825000_2026.03.15.711961v1.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"2026031908050825000_2026.03.15.711961v1.2","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e31829fb7a2"},{"key":"2026031908050825000_2026.03.15.711961v1.3","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181eec14c"},{"key":"2026031908050825000_2026.03.15.711961v1.4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1588"},{"key":"2026031908050825000_2026.03.15.711961v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32591-8"},{"key":"2026031908050825000_2026.03.15.711961v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30532-5"},{"key":"2026031908050825000_2026.03.15.711961v1.7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.3651"},{"key":"2026031908050825000_2026.03.15.711961v1.8","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.0611"},{"key":"2026031908050825000_2026.03.15.711961v1.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6733"},{"key":"2026031908050825000_2026.03.15.711961v1.10","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00706"},{"key":"2026031908050825000_2026.03.15.711961v1.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.06.016"},{"key":"2026031908050825000_2026.03.15.711961v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30516-8"},{"key":"2026031908050825000_2026.03.15.711961v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02848-4"},{"key":"2026031908050825000_2026.03.15.711961v1.14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.0611"},{"key":"2026031908050825000_2026.03.15.711961v1.15","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-22-0412"},{"key":"2026031908050825000_2026.03.15.711961v1.16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00561"},{"key":"2026031908050825000_2026.03.15.711961v1.17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.01.220"},{"key":"2026031908050825000_2026.03.15.711961v1.18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.4140"},{"key":"2026031908050825000_2026.03.15.711961v1.19","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-7334701\/v1"},{"key":"2026031908050825000_2026.03.15.711961v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.09.007"},{"key":"2026031908050825000_2026.03.15.711961v1.21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1921791117"},{"key":"2026031908050825000_2026.03.15.711961v1.22","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796948"},{"key":"2026031908050825000_2026.03.15.711961v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17455-3"},{"key":"2026031908050825000_2026.03.15.711961v1.24","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.02931"},{"key":"2026031908050825000_2026.03.15.711961v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1943-3"},{"key":"2026031908050825000_2026.03.15.711961v1.26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.757804"},{"key":"2026031908050825000_2026.03.15.711961v1.27","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-007440"},{"key":"2026031908050825000_2026.03.15.711961v1.28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00561"},{"key":"2026031908050825000_2026.03.15.711961v1.29","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"key":"2026031908050825000_2026.03.15.711961v1.30","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1588"},{"key":"2026031908050825000_2026.03.15.711961v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32591-8"},{"key":"2026031908050825000_2026.03.15.711961v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"2026031908050825000_2026.03.15.711961v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0363-5"},{"key":"2026031908050825000_2026.03.15.711961v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.08.004"},{"key":"2026031908050825000_2026.03.15.711961v1.35","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0418"},{"key":"2026031908050825000_2026.03.15.711961v1.36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-22-1483"},{"key":"2026031908050825000_2026.03.15.711961v1.37","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1490"},{"key":"2026031908050825000_2026.03.15.711961v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/nature16965"},{"key":"2026031908050825000_2026.03.15.711961v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/nature14169"},{"key":"2026031908050825000_2026.03.15.711961v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00369-2"},{"key":"2026031908050825000_2026.03.15.711961v1.41","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.Am2025-ct004"},{"key":"2026031908050825000_2026.03.15.711961v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/nature12306"},{"key":"2026031908050825000_2026.03.15.711961v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.056"},{"key":"2026031908050825000_2026.03.15.711961v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/nature25432"},{"key":"2026031908050825000_2026.03.15.711961v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.017"},{"key":"2026031908050825000_2026.03.15.711961v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3558"},{"key":"2026031908050825000_2026.03.15.711961v1.47","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03173-w"},{"key":"2026031908050825000_2026.03.15.711961v1.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0127-6"},{"key":"2026031908050825000_2026.03.15.711961v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.005"},{"key":"2026031908050825000_2026.03.15.711961v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.039"},{"key":"2026031908050825000_2026.03.15.711961v1.51","doi-asserted-by":"publisher","DOI":"10.1038\/nature14184"},{"key":"2026031908050825000_2026.03.15.711961v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/nature14157"},{"key":"2026031908050825000_2026.03.15.711961v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2344"},{"key":"2026031908050825000_2026.03.15.711961v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3398"},{"key":"2026031908050825000_2026.03.15.711961v1.55","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-24-3766"},{"key":"2026031908050825000_2026.03.15.711961v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.05.010"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.03.15.711961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:05:19Z","timestamp":1773932719000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.03.15.711961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":56,"URL":"https:\/\/doi.org\/10.64898\/2026.03.15.711961","relation":{},"subject":[],"published":{"date-parts":[[2026,3,17]]},"subtype":"preprint"}}