{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:04:40Z","timestamp":1774447480274,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,23]]},"group-title":"Pediatrics","reference-count":44,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neonatal disorders such as post-infectious hydrocephalus exhibit a higher incidence in Africa, where the intricate relationships between genetic ancestry, environmental exposures, and other risk factors likely contribute to the increased incidence.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To start to characterize the common genetic architecture of Ugandan infants, we analyzed genome sequencing data from 1,030 Ugandan infants recruited from studies targeting neonatal sepsis and hydrocephalus. We employed genetic admixture analysis and integrated geospatial data to examine the relationships between genetic backgrounds and disease prevalence within this cohort.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our results identified four distinct genetic admixture groups, each correlating strongly with specific geographic distributions across Uganda. Notably, a predominance of one admixture group, most common in northern Uganda, was overrepresented in the participants with post-infectious hydrocephalus.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study underscores the importance of genetic factors in disease manifestation at the population level, and a role for such precision public health approaches in complex neonatal disorders in African populations.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.03.16.26348489","type":"posted-content","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:10:14Z","timestamp":1774293014000},"source":"Crossref","is-referenced-by-count":0,"title":["Genome admixture analysis of 1,030 Ugandan infants with neonatal sepsis and hydrocephalus demonstrates geographical stratification of population disease risk"],"prefix":"10.64898","author":[{"given":"Mercedeh","family":"Movassagh","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, CT"},{"name":"Harvard TH Chan School of Public Health, Department of Biostatistics, Boston, MA"},{"name":"Dana Farber Cancer Institute, Department of Data Science, Boston, MA"},{"name":"Boston Children\u2019s Hospital, Division of Newborn Medicine, Department of Pediatrics, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucinda","family":"Newbury","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Hehnly","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital and Harvard Medical School, Department of Pathology, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallory","family":"Peterson","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Department of Neurosurgery, Hershey, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Mondragon-Estrada","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital, Division of Newborn Medicine, Department of Pediatrics, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica E.","family":"Ericson","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Department of Pediatrics, Hershey, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Smith","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, 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