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These deposits grow with age, increasing the risk of age-related macular degeneration (AMD), the leading cause of irreversible vision loss for older adults globally. Current\n                  <jats:italic>in vivo<\/jats:italic>\n                  imaging lacks specificity to study BM and the important spaces at the RPE\/BM interface in living human eyes, while histological techniques suffer from processing artifacts that distort photoreceptors. Here we employ visible light Optical Coherence Tomography (OCT), with 1 micrometer depth resolution, to quantitatively analyze these tissues in living eyes. We identify age-related changes in a human cohort without retinal pathology: thickening and loss of contrast of the hyper-reflective BM band, and thickening of the RPE together with the sub-RPE basal laminar space (RPE+sBL). Both forms of thickening were locally coupled depending on eccentricity, suggesting related biosynthetic mechanisms. A thicker BM and RPE+sBL were locally associated with anomalies in the overlying photoreceptors. Thus, sub-clinical changes in aging eyes detected by visible light OCT resemble early versions of deposits found in AMD. Visible light OCT depicts the relationship between RPE+sBL, BM, and photoreceptors in aging, holding promise to precisely and non-invasively grade ocular phenotypes ranging from normal aging to early AMD.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Significance Statement<\/jats:title>\n                  <jats:p>\n                    As humans age, lipids and other debris deposit in Bruch\u2019s membrane (BM) of the human eye (1) and spaces introduced between the retinal pigment epithelium (RPE) and BM. These deposition processes are linked to the eventual development of age-related macular degeneration (AMD), the leading blinding disease amongst older adults. Here we investigate these deposits with visible light OCT imaging in living human subjects without overt retinal pathology. Whereas early RPE\/BM deposits were previously assessed only in donor eyes\n                    <jats:italic>postmortem<\/jats:italic>\n                    via preparations that distort photoreceptors, our results shed light on these AMD precursors and overlying photoreceptor changes in living human eyes.\n                  <\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.03.18.712487","type":"posted-content","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:05:20Z","timestamp":1774026320000},"source":"Crossref","is-referenced-by-count":0,"title":["Visible Light Optical Coherence Tomography Reveals Aging at the Retinal Pigment Epithelium-Bruch\u2019s Membrane Interface"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0643-1688","authenticated-orcid":false,"given":"Ruoyu","family":"Meng","sequence":"first","affiliation":[{"name":"NYU Tandon School of Engineering, Brooklyn, New York, USA 11201"},{"name":"Tech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel C.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Population Health, NYU Grossman School of Medicine, New York, New York, USA 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moning","family":"Pan","sequence":"additional","affiliation":[{"name":"NYU Tandon School of Engineering, Brooklyn, New York, USA 11201"},{"name":"Tech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Tech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101"},{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasha S.","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Tech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101"},{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Curcio","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016"},{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek J.","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"NYU Tandon School of Engineering, Brooklyn, New York, USA 11201"},{"name":"Tech4Health Institute, NYU Grossman School of Medicine, Long Island City, New York, USA 11101"},{"name":"Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026032405350496000_2026.03.18.712487v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32619-2"},{"key":"2026032405350496000_2026.03.18.712487v1.2","first-page":"364","article-title":"Recent Updates on the Diagnosis and Management of Age-Related Macular Degeneration. 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