{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T17:48:10Z","timestamp":1774806490957,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,25]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,25]]},"abstract":"<jats:title>Abstract\/Summary<\/jats:title>\n                <jats:p>\n                  Task-sharing approaches have shown promise in low-resource settings, yet few culturally adapted interventions have been systematically evaluated for forcibly displaced populations. Since 2016, over 1.7 million Venezuelans have migrated to Peru, facing significant barriers to healthcare and elevated risks of anxiety, depression, and post-traumatic stress disorder (PTSD). This protocol describes COMPASS (Cognitive-behavioral Open-source Mental-health Program Adapted for migrants, Sustainably delivered by lay providers and Supported by evidence). COMPASS is a transdiagnostic, open-source cognitive behavioral therapy program co-designed with forcibly displaced populations. This protocol describes the procedures for an ongoing randomized pilot trial with n = 90 forcibly displaced Venezuelan people (Clinicaltrials.gov:\n                  <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06635486\">NCT06635486<\/jats:ext-link>\n                  ). COMPASS guides, or lay providers, trained through an intensive apprenticeship model, will deliver 6\u201312 weekly remote sessions. Primary outcomes include changes in anxiety, depression, and PTSD symptoms, assessed with validated Spanish-language measures. Secondary outcomes include feasibility (recruitment, retention, fidelity) and acceptability (therapist and participant ratings). Exploratory outcomes will examine integration, migration experiences, and demographic moderators of intervention effectiveness. Analyses will follow the intention-to-treat principle, using descriptive statistics and regression models to evaluate symptom trajectories across baseline, post-intervention, and 3- and 6-month follow-ups. This study represents the first effectiveness evaluation of an open-source, lay-delivered CBT program tailored for forcibly displaced people in Peru. Findings will inform feasibility, acceptability, and preliminary effectiveness of COMPASS, with potential to expand scalable, culturally relevant mental health services for forcibly displaced populations in resource-constrained settings worldwide.\n                <\/jats:p>","DOI":"10.64898\/2026.03.19.26348265","type":"posted-content","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:35:17Z","timestamp":1774632917000},"source":"Crossref","is-referenced-by-count":0,"title":["Protocol for a randomized pilot trial of COMPASS, an open-source, culturally adapted cognitive behavioral therapy program for forcibly displaced Venezuelan adults in Peru"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-860X","authenticated-orcid":false,"given":"Haley A.","family":"Carroll","sequence":"first","affiliation":[{"name":"Boston University Medical Center, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"},{"name":"Universidad del Pacifico, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia","family":"Guevara","sequence":"additional","affiliation":[{"name":"Boston University Medical Center, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"},{"name":"Universidad del Pacifico, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Gamarra","sequence":"additional","affiliation":[{"name":"Boston University Medical Center, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chombalelo","family":"Mukunta","sequence":"additional","affiliation":[{"name":"The Psychology Association of Zambia, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Dorsey","sequence":"additional","affiliation":[{"name":"University of Washington, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bizu","family":"Gelaye","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Henderson","sequence":"additional","affiliation":[{"name":"Boston University Medical Center, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-0505","authenticated-orcid":false,"given":"Matthew D.","family":"Bird","sequence":"additional","affiliation":[{"name":"Universidad del Pacifico, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development; 6710B Rockledge Drive, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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