{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:22:18Z","timestamp":1785424938817,"version":"3.56.0"},"posted":{"date-parts":[[2026,3,23]]},"group-title":"Neuroscience","reference-count":221,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R03NS128372"],"award-info":[{"award-number":["R03NS128372"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"award":["T32NS099042"],"award-info":[{"award-number":["T32NS099042"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neonatal global hypoxic-ischemic cerebral injury is a leading cause of infant mortality and lifelong disability. Current rodent models do not replicate neonatal global cerebral ischemia (nGCI) and reperfusion injury. Here, we developed and characterized a rodent model of cardiac arrest and cardiopulmonary reperfusion (CA\/CPR) to induce nGCI, producing acute systemic ischemia, mild neuronal injury, white matter alterations, and motor and memory deficits.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Rat pups underwent CA\/CPR or sham procedure on postnatal day 9-11. CA\/CPR in rat pups was performed under anesthesia while intubated. Asystole was induced with intravenous (IV) KCl and maintained for 10-14 minutes. Resuscitation included oxygen ventilation, chest compressions, and IV epinephrine.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve minutes of asystole provided an optimal balance between survival and systemic injury. Behavioral testing on postoperative day (POD) 7 revealed memory impairments. Despite the absence of overt neuronal death in the hippocampus or cerebellum, we observed evidence of glial activation and white matter alterations.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This novel rodent model of nGCI addresses limitations in existing models while offering clinically relevant features to support future mechanistic and translational research.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Impact<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>This study validates cardiac arrest and cardiopulmonary resuscitation (CA\/CPR) as a novel model for neonatal global cerebral ischemia (nGCI), complementing existing rodent models of unilateral and permanent injury by enabling investigation of both global ischemia and reperfusion injury.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>nGCI results in memory impairment in the absence of overt neuronal cell death. Functional deficits are associated with neuroinflammatory responses in the hippocampus, white matter, and cerebellum.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Neonatal CA\/CPR induces global cerebral ischemia which uniquely allows investigation of hindbrain structures, such as cerebellum, which are typically spared in existing rodent models of neonatal hypoxia-ischemia.<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.03.19.712953","type":"posted-content","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:05:42Z","timestamp":1774289142000},"source":"Crossref","is-referenced-by-count":0,"title":["Novel neonatal hypoxic-ischemic model demonstrates neuroinflammation-associated memory deficits without neuronal loss"],"prefix":"10.64898","author":[{"given":"Kaylin M.","family":"Langer","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Harmon","sequence":"additional","affiliation":[{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Division of Child Neurology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Fineberg","sequence":"additional","affiliation":[{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Henry","sequence":"additional","affiliation":[{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobella","family":"Veitch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Klopper","sequence":"additional","affiliation":[{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Division of Child Neurology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanner","family":"McVey","sequence":"additional","affiliation":[{"name":"Neuronal Injury and Plasticity Program, University of Colorado Anschutz School of Medicine, Aurora, CO"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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