{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:30:13Z","timestamp":1785875413500,"version":"3.56.0"},"posted":{"date-parts":[[2026,3,24]]},"group-title":"Developmental Biology","reference-count":59,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2023-00273400"],"award-info":[{"award-number":["RS-2023-00273400"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2025-00520263"],"award-info":[{"award-number":["RS-2025-00520263"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2021-NR061427"],"award-info":[{"award-number":["RS-2021-NR061427"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00436657"],"award-info":[{"award-number":["RS-2024-00436657"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00508575"],"award-info":[{"award-number":["RS-2024-00508575"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2022-NR067309"],"award-info":[{"award-number":["RS-2022-NR067309"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["RS-2024-00406488"],"award-info":[{"award-number":["RS-2024-00406488"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AR070313"],"award-info":[{"award-number":["R01-AR070313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Suh Kyungbae Foundation","award":["SUHF-2101005"],"award-info":[{"award-number":["SUHF-2101005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,24]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  Autotomy is a unique phenotype whereby an animal sheds a body part to escape predation\n                  <jats:sup>1\u20133<\/jats:sup>\n                  . The timing and location of autotomy are tightly regulated by preformed planes of weakness (aka fracture planes) which facilitate tissue loss. While autotomy is often followed by regeneration, these phenotypes are rarely reported in mammals\n                  <jats:sup>4\u20139<\/jats:sup>\n                  . A notable exception are spiny mice (\n                  <jats:italic>Acomys<\/jats:italic>\n                  ) which exhibit skin autotomy and more remarkably, complete tissue regeneration\n                  <jats:sup>10\u201314<\/jats:sup>\n                  . Presently, mechanisms underlying autotomy and complete regeneration in\n                  <jats:italic>Acomys<\/jats:italic>\n                  skin remain elusive. Here, we report the discovery of a honeycomb-like fracture lattice in\n                  <jats:italic>Acomys<\/jats:italic>\n                  skin whose design directs tissue destruction but also facilitates regenerative healing. Unlike the single continuous surface of a fracture plane, this fracture lattice consists of a three-dimensional array of hexagonal units whose boundaries guide tissue breakage. Moreover, we identify collagen VI as the main constituent of the fracture lattice and find that it is distinctly arranged to initiate fracturing and propagation of skin tearing. By preconditioning the tissue for autotomy, the fracture lattice dampens the damage-induced inflammatory response but also upregulates a pro-regenerative gene signature, accelerating skin appendage regeneration. Lastly, we discovered the key role of spiny hairs in fracture lattice formation, as inhibiting their development leads to abnormal pattern formation and changes in skin fracture mechanics. Our results present a novel example of a uniquely evolved structural adaptation in mammalian skin that links tissue patterning, autotomy and regeneration. We expect that the application of a modular compartment structure to artificial skin and other organ engineering may enhance resilience to injury and facilitate efficient regeneration.\n                <\/jats:p>","DOI":"10.64898\/2026.03.23.713756","type":"posted-content","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:35:16Z","timestamp":1774359316000},"source":"Crossref","is-referenced-by-count":2,"title":["A novel fracture lattice in spiny mouse skin facilitates tissue autotomy and regeneration"],"prefix":"10.64898","author":[{"given":"Daeryeok","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Chan","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"},{"name":"Division of Mechanical Design Engineering and Advanced Mechanical Components Design & Research Center, Jeonbuk National University; Jeonju-si, Jeonbuk-do, 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunji","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyun","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghwan","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwook","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seulki","family":"You","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tong","sequence":"additional","affiliation":[{"name":"The Hansj\u00f6rg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine; New York, NY, 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine P.","family":"Lu","sequence":"additional","affiliation":[{"name":"The Hansj\u00f6rg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine; New York, NY, 10016, USA"},{"name":"Department of Cell Biology, Regenerative Medicine Institute, New York University Grossman School of Medicine; New York, NY, 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooil","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Ae","family":"Kim","sequence":"additional","affiliation":[{"name":"Core Research Facility & Analysis Center, Korea Research Institute of Bioscience and Biotechnology; Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Yonsei University College of Medicine; Seoul 03722, Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea21 Project, Yonsei University College of Medicine; Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Clemens","sequence":"additional","affiliation":[{"name":"Simons Initiative for the Developing Brain, Institute of Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, University of Edinburgh; Edinburgh, 1 George Square, EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley W.","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Kentucky; Lexington, KY 40506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungbum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeshin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Dong","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology; Daejeon, 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-3664","authenticated-orcid":false,"given":"Hanseul","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology; 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Trim Galore!: A wrapper around Cutadapt and FastQC to consistently apply adapter and quality trimming to FastQ files, with extra functionality for RRBS data. Babraham Institute (2015)."},{"key":"2026032622153913000_2026.03.23.713756v1.57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120897"},{"key":"2026032622153913000_2026.03.23.713756v1.58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jmbbm.2013.07.015","article-title":"Cohesive zone modeling of mode I tearing in thin soft materials","volume":"28","year":"2013","journal-title":"Journal of the mechanical behavior of biomedical materials"},{"key":"2026032622153913000_2026.03.23.713756v1.59","doi-asserted-by":"crossref","unstructured":"Anderson, T. L. & Anderson, T. L . Fracture mechanics: fundamentals and applications. 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