{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:05:21Z","timestamp":1775037921810,"version":"3.50.1"},"posted":{"date-parts":[[2026,3,28]]},"group-title":"Neurology","reference-count":19,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  In the Global Parkinson\u2019s Genetics Program (GP2) we aim to advance precision medicine by integrating large-scale clinico-genetic data from diverse populations worldwide. We investigated potentially trial-eligible carriers of pathogenic and high-risk\n                  <jats:italic>GBA1<\/jats:italic>\n                  and\n                  <jats:italic>LRRK2<\/jats:italic>\n                  variants and conducted a global precision-medicine survey across GP2 sites. Among 65,509 individuals with Parkinson\u2019s disease, we identified 9,019 (13.8%) potentially trial-eligible genetic variant carriers, including 6,789\n                  <jats:italic>GBA1<\/jats:italic>\n                  , 2,084\n                  <jats:italic>LRRK2<\/jats:italic>\n                  , and 146 dual\n                  <jats:italic>GBA1-LRRK2<\/jats:italic>\n                  carriers. Individuals were distributed across multiple global regions, many of which currently lack active gene-targeted trials, highlighting a global disparity between relevant variant carriers and the availability of disease modifying treatment trials. GP2\u2019s unified framework supports equitable recruitment for gene-targeted therapeutic studies and helps address critical gaps in Parkinson\u2019s disease genetics and future therapeutic development.\n                <\/jats:p>","DOI":"10.64898\/2026.03.26.26349418","type":"posted-content","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:20:13Z","timestamp":1774711213000},"source":"Crossref","is-referenced-by-count":0,"title":["Bridging Genetics and Precision Medicine in Parkinson\u2019s Disease through GP2"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-922X","authenticated-orcid":false,"given":"Kajsa","family":"Atterling Brolin","sequence":"first","affiliation":[{"name":"Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden"},{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-9821","authenticated-orcid":false,"given":"Lara M.","family":"Lange","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA"},{"name":"Institute of Neurogenetics, University of Luebeck, Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0353-8545","authenticated-orcid":false,"given":"Emily","family":"Navarro-Jones","sequence":"additional","affiliation":[{"name":"UCL Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK"},{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6030-2901","authenticated-orcid":false,"given":"Simona","family":"Jasaityte","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ye Beh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-8772","authenticated-orcid":false,"given":"Zih-Hua","family":"Fang","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany"},{"name":"DataTecnica, Washington, DC, 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-3431","authenticated-orcid":false,"given":"Christine","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, Luebeck, Germany"},{"name":"Department of Neurology, University Hospital of Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6313-7395","authenticated-orcid":false,"given":"Teresa","family":"Kleinz","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, Luebeck, Germany"},{"name":"Section for Movement Disorders, University Hospital of Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-8110","authenticated-orcid":false,"given":"Hampton L.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA"},{"name":"DataTecnica, Washington, DC, USA"},{"name":"Center for Alzheimer\u2019s and Related Dementias, National Institute on Aging, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-0633","authenticated-orcid":false,"given":"Ignacio F.","family":"Mata","sequence":"additional","affiliation":[{"name":"Genome Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair J","family":"Noyce","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK"},{"name":"Department of Neurology, The Royal London Hospital, Barts Health NHS Trust, London, 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