{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:04:24Z","timestamp":1782281064865,"version":"3.54.5"},"posted":{"date-parts":[[2026,3,31]]},"group-title":"Neuroscience","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"funder":[{"name":"NARSAD Young Investigator Grant","award":["32792"],"award-info":[{"award-number":["32792"]}]},{"name":"Irish Research Council"},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"crossref","award":["HRA-POR-324"],"award-info":[{"award-number":["HRA-POR-324"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Irish Research Council"},{"name":"NIH","award":["R01MH134004"],"award-info":[{"award-number":["R01MH134004"]}]},{"name":"NIH","award":["R01MH129742"],"award-info":[{"award-number":["R01MH129742"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["521379614"],"award-info":[{"award-number":["521379614"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"crossref","award":["2022_EKEA.193"],"award-info":[{"award-number":["2022_EKEA.193"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovative Medical Research","award":["B\u00f6112202"],"award-info":[{"award-number":["B\u00f6112202"]}]},{"name":"Innovative Medical Research","award":["LE112403"],"award-info":[{"award-number":["LE112403"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["DA1151\/5-1, DA1151\/5-2, DA1151\/9-1, DA1151\/10-1, DA1151\/11-1"],"award-info":[{"award-number":["DA1151\/5-1, DA1151\/5-2, DA1151\/9-1, DA1151\/10-1, DA1151\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB\/TRR 393"],"award-info":[{"award-number":["SFB\/TRR 393"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["521379614"],"award-info":[{"award-number":["521379614"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Interdisciplinary Center for Clinical Research","award":["Dan3\/022\/22"],"award-info":[{"award-number":["Dan3\/022\/22"]}]},{"name":"the German Research Foundation","award":["KI588\/14-1, and KI588\/14-2, and KI588\/20-1, KI588\/22-1"],"award-info":[{"award-number":["KI588\/14-1, and KI588\/14-2, and KI588\/20-1, KI588\/22-1"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["STR1146\/18-1"],"award-info":[{"award-number":["STR1146\/18-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agence Nationale pour la Recherche","award":["ANR-11-INBS-0006"],"award-info":[{"award-number":["ANR-11-INBS-0006"]}]},{"name":"Agence Nationale pour la Recherche","award":["ANR-11-IDEX-0004, ANR-10-COHO-10-01"],"award-info":[{"award-number":["ANR-11-IDEX-0004, ANR-10-COHO-10-01"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007380","name":"Fondation de l'Avenir","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["MH077945, MH106324, MH080912"],"award-info":[{"award-number":["MH077945, MH106324, MH080912"]}]},{"name":"Australian National Medical and Health Research Council","award":["1037196, 1177991"],"award-info":[{"award-number":["1037196, 1177991"]}]},{"name":"Lansdowne Foundation, Good Talk, and the Keith Pettigrew Family Bequest"},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["324499"],"award-info":[{"award-number":["324499"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"name":"KG Jebsen Stiftelsen","award":["SKGJ-MED-021"],"award-info":[{"award-number":["SKGJ-MED-021"]}]},{"DOI":"10.13039\/501100004785","name":"Nordforsk","doi-asserted-by":"crossref","award":["164218"],"award-info":[{"award-number":["164218"]}],"id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Southe East Norway Health Authority","award":["2023-031"],"award-info":[{"award-number":["2023-031"]}]},{"name":"Hessian Ministry of Science and Arts","award":["LOEWE1\/16\/519\/03\/09.001(0009)\/98"],"award-info":[{"award-number":["LOEWE1\/16\/519\/03\/09.001(0009)\/98"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["We3638\/3-1, We3638\/5-1 and SFB636\/Project C6"],"award-info":[{"award-number":["We3638\/3-1, We3638\/5-1 and SFB636\/Project C6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Large-scale T1-weighted MRI studies have established grey-matter abnormalities in bipolar disorder (BD), with our group contributing to consensus findings. However, structural connectivity, particularly within emotion- and reward-related circuits, remains poorly understood. Diffusion-weighted MRI (dMRI) enables investigation of white-matter pathways, yet prior work is constrained by small samples, methodological heterogeneity, and unclear medication effects. We conducted the largest dMRI network analysis in BD, relating symptom burden and polypharmacy to tractography-derived connectivity and graph-theoretic metrics.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional structural and diffusion MRI scans from 449 individuals with BD (35.7\u00b112.6 years) and 510 controls (33.3\u00b112.6 years), aged 18\u201365, were analyzed across 16 ENIGMA-BD sites. Standardized segmentation\/parcellation and constrained spherical deconvolution tractography generated individual structural connectivity matrices. Graph-theoretic metrics of global and subnetwork organization were related to symptom severity and medications.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BD showed widespread network alterations (lower density and efficiency, longer path length, and higher betweenness centrality), altered microstructural organization in a limbic\u2013basal ganglia circuit, and abnormal streamline counts in a default-mode\/salience\/fronto-limbic\u2013basal ganglia network. Longer illness duration, later onset, and psychosis history were associated with greater abnormalities in network architecture, whereas more manic episodes were associated with greater fronto-limbic connectivity. Antidepressant (particularly SSRI), anticonvulsant, and antipsychotic use related to poorer global and fronto-limbic connectivity; no clear lithium effects emerged.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>As the largest structural connectivity study in BD, we reveal widespread disruption in reward and emotion-regulation networks influenced by illness severity and medication use. Results show that multisite harmonization is feasible and highlight ENIGMA-BD as a scalable framework for identifying reproducible neurobiological markers.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.03.28.714565","type":"posted-content","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:35:53Z","timestamp":1774982153000},"source":"Crossref","is-referenced-by-count":0,"title":["Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder"],"prefix":"10.64898","author":[{"given":"Leila","family":"Nabulsi","sequence":"first","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"},{"name":"Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody J.Y.","family":"Kang","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"McPhilemy","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona M.","family":"Martyn","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartholomeus","family":"Haarman","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"McDonald","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hallahan","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefani","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"},{"name":"SAMRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur M.","family":"Howells","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freda","family":"Scheffler","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, University of Cape Town, Cape Town, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk S.","family":"Temmingh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Glahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Boston Children\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Boston Children\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Pomarol-Clotet","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Barcelona Bipolar Disorders and Depressive Unit, Hospital Cl\u00ednic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Radua","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Barcelona Bipolar Disorders and Depressive Unit, Hospital Cl\u00ednic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Salvador","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriana","family":"Karuk","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick J.","family":"Canales-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation, Barcelona, Spain"},{"name":"Signal Processing Laboratory (LTS5), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josselin","family":"Houenou","sequence":"additional","affiliation":[{"name":"INSERM U955, team \u201cTranslational Neuro-Psychiatry\u201d, Cr\u00e9teil, France"},{"name":"Northern Health, Mental Health Division, Melbourne, Victoria, Australia, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Favre","sequence":"additional","affiliation":[{"name":"INSERM U955, team \u201cTranslational Neuro-Psychiatry\u201d, Cr\u00e9teil, France"},{"name":"Neurospin, CEA Paris-Saclay, team UNIACT, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Polosan","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France"},{"name":"INSERM U1216 - Grenoble Institut des Neurosciences, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Pouchon","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France"},{"name":"INSERM U1216 - Grenoble Institut des Neurosciences, La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy"},{"name":"Department of Neurosciences and Mental Health, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Bellani","sequence":"additional","affiliation":[{"name":"Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip B.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Roberts","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Dannlowski","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"},{"name":"Bielefeld University, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Department of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiana","family":"Borgers","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Meinert","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Flinkenfl\u00fcgel","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Repple","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"},{"name":"Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany"},{"name":"Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J.","family":"Leehr","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Grotegerd","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hahn","sequence":"additional","affiliation":[{"name":"Institute for Translational Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Wessa","sequence":"additional","affiliation":[{"name":"Central Institut of Mental Health, Department of Neuropsychology and Psychological Resilience Research, Mannheim, Germany"},{"name":"DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Germany"},{"name":"German Cancer Research Center (DKFZ) Heidelberg, Department of Cancer Survivorship and Psychological Resilience, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Teutenberg","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Straube","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Steinstraeter","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Stein","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Thomas-Odenthal","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Alexander","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula L","family":"Usemann","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jansen","sequence":"additional","affiliation":[{"name":"Philipps-Universit\u00e4t Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany"},{"name":"Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia"},{"name":"Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, VIC, Australia"},{"name":"Deakin University, IMPACT Institute, School of Medicine, Deakin University, Geelong VIC, Australia"},{"name":"Orygen Youth Health Clinical Program, 35 Poplar Road, Parkville VIC 3052, Australia"},{"name":"Barwon Health and the Geelong Clinic, Geelong, VIC 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orwa","family":"Dandash","sequence":"additional","affiliation":[{"name":"Brain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC 3168, Australia"},{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Parker","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Suo","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Science and Monash Biomedical Imaging, Monash University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia I.","family":"Thomopoulos","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R. K.","family":"Ching","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ENIGMA Bipolar Disorder Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026040309151154000_2026.03.28.714565v1.1","doi-asserted-by":"crossref","unstructured":"Ab\u00e9 C , Ching CRK , Liberg B , Lebedev A V , Agartz I , Akudjedu TN , Alda M , Aln\u00e6s D , Alonso-Lana S , Benedetti F , Berk M , B\u00f8en E , Bonnin CDM , Breuer F , Brosch K , Brouwer RM , Canales-Rodr\u00edguez EJ , Cannon DM , Chye Y , Dahl A , Dandash O , Dannlowski U , Dohm K , Elvs\u00e5shagen T , Fisch L , Fullerton JM , Goikolea JM , Grotegerd D , Haatveit B , Hahn T , Hajek T , Heindel W , Ingvar M , Sim K , Kircher TTJ , Lenroot RK , Malt UF , McDonald C , McWhinney SR , Melle I , Meller T , Melloni EMT , Mitchell PB , Nabulsi L , Nenadi\u0107 I , Opel N , Overs BJ , Panicalli F , Pfarr J-K , Poletti S , Pomarol-Clotet E , Radua J , Repple J , Ringwald KG , Roberts G , Rodriguez-Cano E , Salvador R , Sarink K , Sarr\u00f3 S , Schmitt S , Stein F , Suo C , Thomopoulos SI , Tronchin G , Vieta E , Westlye LT , White AG , Yatham LN , Zak N , Thompson PM , Andreassen OA , Land\u00e9n M . 2021. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biol Psychiatry.","DOI":"10.1016\/j.biopsych.2021.09.008"},{"issue":"4","key":"2026040309151154000_2026.03.28.714565v1.2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1017\/S1092852900020800","article-title":"Brain network dysfunction in bipolar disorder","volume":"11","year":"2006","journal-title":"CNS spectrums"},{"key":"2026040309151154000_2026.03.28.714565v1.3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpsychires.2015.05.017","article-title":"Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder","volume":"68","year":"2015","journal-title":"J Psychiatr Res"},{"key":"2026040309151154000_2026.03.28.714565v1.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.143959"},{"key":"2026040309151154000_2026.03.28.714565v1.5","doi-asserted-by":"publisher","DOI":"10.2307\/2346101"},{"key":"2026040309151154000_2026.03.28.714565v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.05.047"},{"key":"2026040309151154000_2026.03.28.714565v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"2026040309151154000_2026.03.28.714565v1.8","doi-asserted-by":"crossref","unstructured":"Ching CRK , Hibar DP , Gurholt TP , Nunes A , Thomopoulos SI , Ab\u00e9 C , Agartz I , Brouwer RM , Cannon DM , de Zwarte SMC , Eyler LT , Favre P , Hajek T , Haukvik UK , Houenou J , Land\u00e9n M , Lett TA , McDonald C , Nabulsi L , Patel Y , Pauling ME , Paus T , Radua J , Soeiro-de-Souza MG , Tronchin G , van Haren NEM , Vieta E , Walter H , Zeng LL , Alda M , Almeida J , Aln\u00e6s D , Alonso-Lana S , Altimus C , Bauer M , Baune BT , Bearden CE , Bellani M , Benedetti F , Berk M , Bilderbeck AC , Blumberg HP , B\u00f8en E , Bollettini I, del Mar Bonnin C, Brambilla P , Canales-Rodr\u00edguez EJ , Caseras X , Dandash O , Dannlowski U , Delvecchio G , D\u00edaz-Zuluaga AM , Dima D , Duchesnay \u00c9 , Elvs\u00e5shagen T , Fears SC , Frangou S , Fullerton JM , Glahn DC , Goikolea JM , Green MJ , Grotegerd D , Gruber O , Haarman BCM , Henry C , Howells FM , Ives-Deliperi V , Jansen A , Kircher TTJ , Kn\u00f6chel C , Kramer B , Lafer B , L\u00f3pez-Jaramillo C , Machado-Vieira R , MacIntosh BJ , Melloni EMT , Mitchell PB , Nenadic I , Nery F , Nugent AC , Oertel V , Ophoff RA , Ota M , Overs BJ , Pham DL , Phillips ML , Pineda-Zapata JA , Poletti S , Polosan M , Pomarol-Clotet E , Pouchon A , Quid\u00e9 Y , Rive MM , Roberts G , Ruhe HG , Salvador R , Sarr\u00f3 S , Satterthwaite TD , Schene AH , Sim K , Soares JC , St\u00e4blein M , Stein DJ , Tamnes CK , Thomaidis G V. , Upegui CV , Veltman DJ , Wessa M , Westlye LT , Whalley HC , Wolf DH , Wu MJ , Yatham LN , Zarate CA , Thompson PM , Andreassen OA . 2020. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 1\u201327.","DOI":"10.1002\/hbm.25098"},{"key":"2026040309151154000_2026.03.28.714565v1.9","doi-asserted-by":"crossref","unstructured":"Crossley NA , Mechelli A , Scott J , Carletti F , Fox PT , Mcguire P , Bullmore ET . 2014. The hubs of the human connectome are generally implicated in the anatomy of brain disorders. Brain.","DOI":"10.1093\/brain\/awu132"},{"key":"2026040309151154000_2026.03.28.714565v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"2026040309151154000_2026.03.28.714565v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0485-6"},{"key":"2026040309151154000_2026.03.28.714565v1.12","doi-asserted-by":"crossref","unstructured":"Fischl B . 2012. FreeSurfer. Neuroimage.","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"2026040309151154000_2026.03.28.714565v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.08.004"},{"key":"2026040309151154000_2026.03.28.714565v1.14","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22324"},{"key":"2026040309151154000_2026.03.28.714565v1.15","unstructured":"Hibar DP , Westlye LT , Doan NT , Jahanshad N , Cheung JW , Ching CRK , Versace A , Bilderbeck AC , Uhlmann A , Mwangi B , Kr\u00e4mer B , Overs B , Hartberg CB , Ab\u00e9 C , Dima D , Grotegerd D , Sprooten E , B\u00f8en E , Jimenez E , Howells FM , Delvecchio G , Temmingh H , Starke J , Almeida JRC , Goikolea JM , Houenou J , Beard LM , Rauer L , Abramovic L , Bonnin M , Ponteduro MF , Keil M , Rive MM , Yao N , Yalin N , Najt P , Rosa PG , Redlich R , Trost S , Hagenaars S , Fears SC , Alonso-Lana S , van Erp TGM , Nickson T , Chaim-Avancini TM , Meier TB , Elvs\u00e5shagen T , Haukvik UK , Lee WH , Schene AH , Lloyd AJ , Young AH , Nugent A , Dale AM , Pfennig A , McIntosh AM , Lafer B , Baune BT , Ekman CJ , Zarate CA , Bearden CE , Henry C , Simhandl C , McDonald C , Bourne C , Stein DJ , Wolf DH , Cannon DM , Glahn DC , Veltman DJ , Pomarol-Clotet E , Vieta E , Canales-Rodriguez EJ , Nery FG , Duran FLS , Busatto GF , Roberts G , Pearlson GD , Goodwin GM , Kugel H , Whalley HC , Ruhe HG , Soares JC , Fullerton JM , Rybakowski JK , Savitz J , Chaim KT , Fatj\u00f3-Vilas M , Soeiro-de-Souza MG , Boks MP , Zanetti M V , Otaduy MCG , Schaufelberger MS , Alda M , Ingvar M , Phillips ML , Kempton MJ , Bauer M , Land\u00e9n M , Lawrence NS , van Haren NEM , Horn NR , Freimer NB , Gruber O , Schofield PR , Mitchell PB , Kahn RS , Lenroot R , Machado-Vieira R , Ophoff RA , Sarr\u00f3 S , Frangou S , Satterthwaite TD , Hajek T , Dannlowski U , Malt UF , Arolt V , Gattaz WF , Drevets WC , Caseras X , Agartz I , Thompson PM , Andreassen OA . 2017. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 1\u201311."},{"key":"2026040309151154000_2026.03.28.714565v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.227"},{"key":"2026040309151154000_2026.03.28.714565v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002010"},{"key":"2026040309151154000_2026.03.28.714565v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.002"},{"key":"2026040309151154000_2026.03.28.714565v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"2026040309151154000_2026.03.28.714565v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.014"},{"key":"2026040309151154000_2026.03.28.714565v1.21","doi-asserted-by":"crossref","first-page":"e100760","DOI":"10.1136\/gpsych-2022-100760","article-title":"Bipolar depression: a review of treatment options","volume":"35","year":"2022","journal-title":"Gen Psychiatr"},{"key":"2026040309151154000_2026.03.28.714565v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.010"},{"key":"2026040309151154000_2026.03.28.714565v1.23","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0039-0"},{"key":"2026040309151154000_2026.03.28.714565v1.24","first-page":"136","article-title":"The underlying neurobiology of bipolar disorder","volume":"2","year":"2003","journal-title":"World Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.25","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1080\/03007995.2019.1636017","article-title":"Bipolar depression: the clinical characteristics and unmet needs of a complex disorder","volume":"35","year":"2019","journal-title":"Curr Med Res Opin"},{"key":"2026040309151154000_2026.03.28.714565v1.26","first-page":"30","article-title":"Newer anticonvulsants: dosing strategies and cognition in treating patients with mood disorders and epilepsy","volume":"64","year":"2003","journal-title":"Journal of Clinical Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.27","doi-asserted-by":"crossref","unstructured":"Menon V . 2015. Salience Network, Brain Mapping: An Encyclopedic Reference. Elsevier Inc.","DOI":"10.1016\/B978-0-12-397025-1.00052-X"},{"key":"2026040309151154000_2026.03.28.714565v1.28","first-page":"1","article-title":"Insula of the Old World Monkey","volume":"22","year":"1982","journal-title":"I : Architectonics in the Insulo-orbito-temporal Component of the"},{"key":"2026040309151154000_2026.03.28.714565v1.29","doi-asserted-by":"crossref","unstructured":"Nabulsi L , Chandio BQ , McPhilemy G , Martyn FM , Roberts G , Hallahan B , Dannlowski U , Kircher T , Haarman B , Mitchell P , McDonald C , Cannon DM , Andreassen OA , Ching CRK , Thompson PM . 2023. Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry. In: 2023 19th International Symposium on Medical Information Processing and Analysis (SIPAIM). p. 1\u20135.","DOI":"10.1109\/SIPAIM56729.2023.10373494"},{"key":"2026040309151154000_2026.03.28.714565v1.30","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/s41386-022-01268-7","article-title":"Normalization of impaired emotion inhibition in bipolar disorder mediated by cholinergic neurotransmission in the cingulate cortex","volume":"47","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"2026040309151154000_2026.03.28.714565v1.31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/brain.2019.0667","article-title":"Bipolar Disorder and Gender Are Associated with Frontolimbic and Basal Ganglia Dysconnectivity: A Study of Topological Variance Using Network Analysis","volume":"9","year":"2019","journal-title":"Brain Connect"},{"key":"2026040309151154000_2026.03.28.714565v1.32","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab356"},{"key":"2026040309151154000_2026.03.28.714565v1.33","doi-asserted-by":"crossref","unstructured":"O\u2019Donoghue S , Cannon DM , Perlini C , Brambilla P , McDonald C . 2015. Applying neuroimaging to detect neuroanatomical dysconnectivity in psychosis. Epidemiol Psychiatr Sci. 1\u20135.","DOI":"10.1017\/S2045796015000074"},{"key":"2026040309151154000_2026.03.28.714565v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.015"},{"key":"2026040309151154000_2026.03.28.714565v1.35","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1017\/S0033291717000058","article-title":"Anatomical integration and rich-club connectivity in euthymic bipolar disorder","volume":"47","year":"2017","journal-title":"Psychol Med"},{"key":"2026040309151154000_2026.03.28.714565v1.36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s42003-022-03963-z","article-title":"Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology","volume":"5","year":"2022","journal-title":"Commun Biol"},{"key":"2026040309151154000_2026.03.28.714565v1.37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jamapsychiatry.2020.2694","article-title":"Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders","volume":"78","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.38","doi-asserted-by":"crossref","unstructured":"Perry A , Roberts G , Mitchell PB , Breakspear M . 2018. Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks. Mol Psychiatry.","DOI":"10.1038\/s41380-018-0267-2"},{"key":"2026040309151154000_2026.03.28.714565v1.39","doi-asserted-by":"crossref","unstructured":"Phillips ML , Ladouceur CD , Drevets WC, ML Phillips ; CD Ladouceur; WC Drevets. 2008. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry. 13:829\u2013857.","DOI":"10.1038\/mp.2008.65"},{"key":"2026040309151154000_2026.03.28.714565v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.216"},{"key":"2026040309151154000_2026.03.28.714565v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"2026040309151154000_2026.03.28.714565v1.42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jamapsychiatry.2013.4513","article-title":"A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity","volume":"71","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.11.011"},{"key":"2026040309151154000_2026.03.28.714565v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.023"},{"key":"2026040309151154000_2026.03.28.714565v1.45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01022.x"},{"key":"2026040309151154000_2026.03.28.714565v1.46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41398-020-0705-1","article-title":"ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries","volume":"10","year":"2020","journal-title":"Transl Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4465-11.2011"},{"key":"2026040309151154000_2026.03.28.714565v1.48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2128-13.2013"},{"key":"2026040309151154000_2026.03.28.714565v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.06.005"},{"key":"2026040309151154000_2026.03.28.714565v1.50","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","year":"2017","journal-title":"The Lancet."},{"key":"2026040309151154000_2026.03.28.714565v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.001"},{"key":"2026040309151154000_2026.03.28.714565v1.52","doi-asserted-by":"crossref","unstructured":"Wang Y , Deng F , Jia Y , Junjing W , Zhong S , Huiyuan H , Chen L , Guanmao C , Hu H , Huang L , Huang R . 2018. Disrupted rich club organization and structural brain connectome in unmedicated bipolar disorder. Psychol Med. 1\u20139.","DOI":"10.1017\/S0033291718001150"},{"issue":"2","key":"2026040309151154000_2026.03.28.714565v1.53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jaac.2017.11.014","article-title":"Longitudinal diffusion tensor imaging study of adolescents and young adults with bipolar disorder","volume":"57","year":"2018","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"key":"2026040309151154000_2026.03.28.714565v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.027"},{"key":"2026040309151154000_2026.03.28.714565v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"2026040309151154000_2026.03.28.714565v1.56","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1017\/S2045796020000803","article-title":"Default mode network activity in bipolar disorder","volume":"29","year":"2020","journal-title":"Epidemiology and psychiatric sciences"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.03.28.714565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:15:58Z","timestamp":1782278158000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.03.28.714565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":56,"URL":"https:\/\/doi.org\/10.64898\/2026.03.28.714565","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1016\/j.biopsych.2026.04.020","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2026,3,31]]},"subtype":"preprint"}}