{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:09:54Z","timestamp":1775293794287,"version":"3.50.1"},"posted":{"date-parts":[[2026,4,1]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":23,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>New tuberculosis (TB) vaccines for adults and adolescents could transform TB prevention programs, but their impact depends on successful implementation. We investigated willingness to be vaccinated with a new TB vaccine in a high HIV and TB burden setting in southern Mozambique in 2024 using a mixed methods approach involving a cross-sectional survey and concurrent in-depth interviews. In 151 surveys and 23 interviews, we found that willingness to receive a new TB vaccine among adults and adolescents was 77% (148\/192) overall. In multivariable analysis, adolescents were more willing to receive a new TB vaccine than adults even when adjusting for other factors which may influence vaccination decisions (adjusted OR: 5.6, 95% CI: 1.7-17.7). Personal experience with TB and greater knowledge of the disease was also linked with willingness to be vaccinated. Qualitative findings reinforced quantitative findings, further clarifying that even among those who expressed hesitancy, a safe and effective TB vaccine endorsed by healthcare workers, government agencies, and community leaders would likely have high uptake. Our findings are specific to southern Mozambique and can shape vaccine introduction efforts after a TB vaccine is licensed and approved for use in this age group.<\/jats:p>","DOI":"10.64898\/2026.03.30.26349798","type":"posted-content","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:10:18Z","timestamp":1775074218000},"source":"Crossref","is-referenced-by-count":0,"title":["Attitudes towards new tuberculosis vaccines among adults, adolescents and their caregivers in southern Mozambique, 2024"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-4385","authenticated-orcid":false,"given":"Agostinho","family":"Lima","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a (CISM), Manhi\u00e7a, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Campos","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Hubert Department of Global Health, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1457-8191","authenticated-orcid":false,"given":"Doyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Department of Epidemiology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machi","family":"Shiiba","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Department of Epidemiology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa Marie","family":"Cranmer","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Department of Epidemiology, Atlanta, GA, USA"},{"name":"Emory University School of Medicine, Department of Pediatrics, Atlanta, GA, USA"},{"name":"Children\u2019s Healthcare of Atlanta, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sozinho","family":"Ac\u00e1cio","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a (CISM), Manhi\u00e7a, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto L.","family":"Garc\u00eda-Basteiro","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade da Manhi\u00e7a (CISM), Manhi\u00e7a, Mozambique"},{"name":"Barcelona Institute for Global Health, ISGlobal, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2900-6070","authenticated-orcid":false,"given":"Lavanya","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Hubert Department of Global Health, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-2909","authenticated-orcid":false,"given":"Kristin","family":"Nelson","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health, Department of Epidemiology, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026040401251179000_2026.03.30.26349798v1.1","unstructured":"Global Tuberculosis Report 2025. https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-andlung-health\/tb-reports\/global-tuberculosis-report-2025."},{"key":"2026040401251179000_2026.03.30.26349798v1.2","unstructured":"Frick, M. 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