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We developed a \u03b2-Cyclodextrin-poly(\u03b2-Amino Ester) nanoparticle system to deliver the histone deactylase inhibitor (HDACi) Panobinostat to MB by the intrathecal route. Various imaging methods were utilized to study nanoparticle and payload fate following infusion into the cerebrospinal fluid (CSF) of mice via cisterna magna or lumbar access points. Nanoparticles dramatically improved penetration of hydrophobic small molecules into distal regions of the spinal cord. Panobinostat-loaded nanoparticles were effective at treating patient-derived MB, activating pharmacodynamic targets, slowing growth of the primary tumor, decreasing incidence of metastasis at the time of death, and ultimately prolonging survival. These studies provide insight into the mechanisms mediating transport of colloids and therapeutic molecules in the subarachnoid space and highlight new approaches for treating metastatic disease in the CNS.<\/jats:p>","DOI":"10.64898\/2026.03.31.715392","type":"posted-content","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:00:17Z","timestamp":1775167217000},"source":"Crossref","is-referenced-by-count":0,"title":["Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route"],"prefix":"10.64898","author":[{"given":"Oluwatobi","family":"Babayemi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Rice University, Houston, TX"},{"name":"Department of Neurological Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX"},{"name":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, 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TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Morton","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Fan","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, UMass Chan Medical School, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey K.","family":"Sablatura","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Baquer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Reagan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Stopka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie R.","family":"Agar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sevick-Muraca","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University of Texas Health 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