{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:24:00Z","timestamp":1794000240577,"version":"4.8.0"},"posted":{"date-parts":[[2026,4,3]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":106,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Sustained attention is an important neurobiological process impaired in multiple neurodevelopmental disorders, including attention-deficit\/hyperactivity disorder (ADHD) and autism. Connectome-based predictive models (CPMs) of sustained attention function and autism symptoms generalize across samples, but whether their features are shared or phenotype-specific is unknown. We tested within-phenotype consistency and across-phenotype specificity in 5 published CPMs predicting autism symptoms or sustained attention performance in youth and adults, equating model size (top 1,000 positively and negatively predictive edges per model). No edge or network pair was shared by all 5 models. Same-phenotype models were nonetheless consistent: the whole-brain pattern of edge-behavior associations correlated in all 4 same-phenotype dataset pairs (r &gt; 0.13, P &lt; 0.005). Features were also largely phenotype-specific: only 1 of 6 cross-phenotype pairs correlated significantly (negatively), and 2 models built to predict autism symptoms vs. attention in the same dataset shared no more edges than chance. Finally, representational similarity analysis revealed that scan type (rest vs. task), participant age, and autism diagnosis did not explain similarity in edge-behavior associations across datasets. Together, these results suggest that feature sets are reproducible within, but distinct across, phenotypes, consistent with autism symptoms and sustained attention being related but separable.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>We interrogated five previously published, transdiagnostic models of sustained attention and autistic phenotypes<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Functional connectome-based models shared edges and networks when phenotypes were similar<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Models predicting attention phenotypes shared more similar features with each other than models predicting autism symptoms and vice-versa<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Age, functional run type, and diagnosis did not affect model similarity<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.01.26349372","type":"posted-content","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:10:15Z","timestamp":1775229015000},"source":"Crossref","is-referenced-by-count":1,"title":["Feature overlap in models of sustained attention and autism symptoms"],"prefix":"10.64898","author":[{"given":"Corey","family":"Horien","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, PA, 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