{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:15:13Z","timestamp":1775578513477,"version":"3.50.1"},"posted":{"date-parts":[[2026,4,4]]},"group-title":"Epidemiology","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Stressful life events impact individual\u2019s functionality and contribute to disease outcomes, yet the biological pathways underlying life stress remain unclear. We characterized the metabolomic profiles of stressful life events using data from 3,264 participants (5,163 observations) of the Dutch NESDA cohort. 98 metabolites were identified, with upregulated metabolites overrepresented in phosphatidylethanolamine and downregulated metabolites overrepresented in fatty acid metabolism. 92 of these metabolites were available in the Dutch NEO cohort (N=599): 11 were significantly replicated including six lipids (e.g., three bile acids (glycochenodeoxycholate 3-sulfate)), one carbohydrate, and one xenobiotic. 21 overlapping metabolites were additionally available in the Chinese GBCS cohort (N=200): 10-undecenoate (11:1n1) (fatty acid) and glycochenodeoxycholate 3-sulfate (bile acid) showed consistent associations across both Dutch and Chinese cohorts. Stressful life events are associated with metabolic dysregulation, particularly involving fatty acid and bile acid pathways, highlighting promising biological targets to reduce the impact of stress on mental and somatic health.<\/jats:p>","DOI":"10.64898\/2026.04.02.26350045","type":"posted-content","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:30:14Z","timestamp":1775316614000},"source":"Crossref","is-referenced-by-count":0,"title":["The Metabolomic Signature of Stressful Life Events"],"prefix":"10.64898","author":[{"given":"Yumeng","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruifang","family":"Li-Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahani","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Brydges","sequence":"additional","affiliation":[{"name":"West Coast Metabolomics Center, University of California, Davis, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-0923","authenticated-orcid":false,"given":"Matthias","family":"Arnold","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Mahmoudiandehkordi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabi","family":"Kastenm\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis O.","family":"Mook-Kanamori","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J.","family":"Giltay","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Sun Yat-Sen University, Guangzhou, China"},{"name":"School of Public Health, The University of Hong Kong, Hong Kong, China"},{"name":"Greater Bay Area Public Health Research Collaboration, Guangdong-Hong Kong-Macao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Sun Yat-Sen University, Guangzhou, China"},{"name":"Greater Bay Area Public Health Research Collaboration, Guangdong-Hong Kong-Macao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands"},{"name":"Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomaz","family":"Bastiaanssen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda W.J.H.","family":"Penninx","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands"},{"name":"Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Kaddurah-Daouk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"},{"name":"Department of Medicine, Duke University, Durham, NC, USA"},{"name":"Duke Institute of Brain Sciences, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Milaneschi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands"},{"name":"Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026040708251144000_2026.04.02.26350045v1.1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691616646305"},{"key":"2026040708251144000_2026.04.02.26350045v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17019-0"},{"key":"2026040708251144000_2026.04.02.26350045v1.3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41440-019-0331-6","article-title":"Stressful life events and augmentation index: results from the Cardiovascular and Metabolic Diseases Etiology Research Center","volume":"43","year":"2020","journal-title":"Hypertens Res"},{"key":"2026040708251144000_2026.04.02.26350045v1.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.010931"},{"key":"2026040708251144000_2026.04.02.26350045v1.5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010418-102857"},{"key":"2026040708251144000_2026.04.02.26350045v1.6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1037\/pspp0000381","article-title":"Longitudinal associations between negative life events and depressive symptoms-A 9-year longitudinal study on between-person and within-person effects and the role of family history","volume":"121","year":"2021","journal-title":"Journal of personality and social psychology"},{"key":"2026040708251144000_2026.04.02.26350045v1.7","doi-asserted-by":"crossref","unstructured":"Hua, Y. et al. Associations of recent stressful life events with anxiety symptoms among Chinese adolescents with a consideration of family functioning. Eur J Psychotraumatol 15, 2337577 (2024).","DOI":"10.1080\/20008066.2024.2337577"},{"key":"2026040708251144000_2026.04.02.26350045v1.8","doi-asserted-by":"crossref","unstructured":"Siew, R. V. K. , Nabe-Nielsen, K. , Turner, A. I. , Bujtor, M. & Torres, S. J . The role of combined modifiable lifestyle behaviors in the association between exposure to stressors and allostatic load: A systematic review of observational studies. Psychoneuroendocrinology 138, 105668 (2022).","DOI":"10.1016\/j.psyneuen.2022.105668"},{"key":"2026040708251144000_2026.04.02.26350045v1.9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41569-024-01024-y","article-title":"Stress and cardiovascular disease: an update","volume":"21","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026040708251144000_2026.04.02.26350045v1.10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41574-022-00746-8","article-title":"The multiple roles of life stress in metabolic disorders","volume":"19","year":"2023","journal-title":"Nature reviews. Endocrinology"},{"key":"2026040708251144000_2026.04.02.26350045v1.11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031912-114452"},{"key":"2026040708251144000_2026.04.02.26350045v1.12","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1857"},{"key":"2026040708251144000_2026.04.02.26350045v1.13","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/obr.12915","article-title":"The association between psychological stress and metabolic syndrome: A systematic review and meta-analysis","volume":"20","year":"2019","journal-title":"Obesity reviews : an official journal of the International Association for the Study of Obesity"},{"key":"2026040708251144000_2026.04.02.26350045v1.14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jpsychores.2014.10.009","article-title":"Relationships between stressful life events and impaired fasting glucose among left-behind farmers in rural China","volume":"78","year":"2015","journal-title":"J Psychosom Res"},{"key":"2026040708251144000_2026.04.02.26350045v1.15","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-013-9473-y"},{"key":"2026040708251144000_2026.04.02.26350045v1.16","doi-asserted-by":"crossref","unstructured":"Tosato, S. et al. Childhood and Adulthood Severe Stressful Experiences and Biomarkers Related to Glucose Metabolism: A Possible Association? Frontiers in psychiatry 12, 629137 (2021).","DOI":"10.3389\/fpsyt.2021.629137"},{"key":"2026040708251144000_2026.04.02.26350045v1.17","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1027"},{"key":"2026040708251144000_2026.04.02.26350045v1.18","doi-asserted-by":"crossref","first-page":"e2021042","DOI":"10.4178\/epih.e2021042","article-title":"Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea","volume":"43","year":"2021","journal-title":"Epidemiology and health"},{"key":"2026040708251144000_2026.04.02.26350045v1.19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/PSY.0000000000000621","article-title":"Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community","volume":"80","year":"2018","journal-title":"Psychosom Med"},{"key":"2026040708251144000_2026.04.02.26350045v1.20","doi-asserted-by":"crossref","unstructured":"Colicino, E. et al. Maternal steroids during pregnancy and their associations with exposure to lifetime stressful life events, prenatal stress appraisal and psychological functioning. Psychoneuroendocrinology 158, 106395 (2023).","DOI":"10.1016\/j.psyneuen.2023.106395"},{"key":"2026040708251144000_2026.04.02.26350045v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.03.026"},{"key":"2026040708251144000_2026.04.02.26350045v1.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb01360.x"},{"key":"2026040708251144000_2026.04.02.26350045v1.23","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1038\/s41380-024-02613-6","article-title":"The metabolome-wide signature of major depressive disorder","volume":"29","year":"2024","journal-title":"Molecular psychiatry"},{"key":"2026040708251144000_2026.04.02.26350045v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0722-x"},{"key":"2026040708251144000_2026.04.02.26350045v1.25","unstructured":"Jansen, R. , Mandaviya, P. , Bastiaanssen, T. F. S. , Kuplicki, R. , Milaneschi, Y. , Dehkordi, S. M. , Bhattacharya, S. , Dunlop, B. W. , Rush, A. J. , Paulus, M. P. , Penninx, B. W. J. H. , Kaddurah-Daouk, R. Metabolome-Wide signature of Anxiety Disorder: Prominence of Panic Disorder (Unpublished manuscript, 2026)."},{"key":"2026040708251144000_2026.04.02.26350045v1.26","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800360017003"},{"key":"2026040708251144000_2026.04.02.26350045v1.27","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9801-3"},{"key":"2026040708251144000_2026.04.02.26350045v1.28","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/liv.15575","article-title":"Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways","volume":"43","year":"2023","journal-title":"Liver international : official journal of the International Association for the Study of the Liver"},{"key":"2026040708251144000_2026.04.02.26350045v1.29","doi-asserted-by":"crossref","unstructured":"Faquih, T. et al. A Workflow for Missing Values Imputation of Untargeted Metabolomics Data. Metabolites 10 (2020).","DOI":"10.3390\/metabo10120486"},{"key":"2026040708251144000_2026.04.02.26350045v1.30","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl131"},{"key":"2026040708251144000_2026.04.02.26350045v1.31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/gps.4370","article-title":"Stress across the life course and depression in a rapidly developing population: the Guangzhou Biobank Cohort Study","volume":"31","year":"2016","journal-title":"International journal of geriatric psychiatry"},{"key":"2026040708251144000_2026.04.02.26350045v1.32","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1038\/s41380-024-02492-x","article-title":"Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression","volume":"29","year":"2024","journal-title":"Molecular psychiatry"},{"key":"2026040708251144000_2026.04.02.26350045v1.33","unstructured":"Oebiotech. Level One 500 Metabolomics Platform, <https:\/\/www.oebiotech.com\/daixiezufuwu\/levelone500.html> (2025)."},{"key":"2026040708251144000_2026.04.02.26350045v1.34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2014.04.042","article-title":"Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress","volume":"273","year":"2014","journal-title":"Neuroscience"},{"key":"2026040708251144000_2026.04.02.26350045v1.35","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/1873-3468.14992","article-title":"The non-enzymatic oxidation of phosphatidylethanolamine and phosphatidylserine and their intriguing roles in inflammation dynamics and diseases","volume":"598","year":"2024","journal-title":"FEBS Lett"},{"key":"2026040708251144000_2026.04.02.26350045v1.36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2018.10.003","article-title":"Modulation of the inflammatory response of immune cells in human peripheral blood by oxidized arachidonoyl aminophospholipids","volume":"660","year":"2018","journal-title":"Arch Biochem Biophys"},{"issue":"176","key":"2026040708251144000_2026.04.02.26350045v1.37","first-page":"57","article-title":"Modified phosphatidylethanolamines induce different levels of cytokine expression in monocytes and dendritic cells","volume":"175","year":"2013","journal-title":"Chem Phys Lipids"},{"key":"2026040708251144000_2026.04.02.26350045v1.38","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/jasms.3c00083","article-title":"Utilization of LC-MS\/MS and Drift Tube Ion Mobility for Characterizing Intact Oxidized Arachidonate-Containing Glycerophosphatidylethanolamine","volume":"34","year":"2023","journal-title":"J Am Soc Mass Spectrom"},{"key":"2026040708251144000_2026.04.02.26350045v1.39","doi-asserted-by":"crossref","unstructured":"Rong, J. , He, T. , Zhang, J. , Bai, Z. & Shi, B . Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure. Lipids Health Dis 22, 66 (2023).","DOI":"10.1186\/s12944-023-01832-0"},{"key":"2026040708251144000_2026.04.02.26350045v1.40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2025.07.042","article-title":"Valvular oxidized phospholipids correlate with severity of human aortic valvular stenosis","volume":"239","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"2026040708251144000_2026.04.02.26350045v1.41","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2116\/analsci.18P281","article-title":"Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish","volume":"34","year":"2018","journal-title":"Anal Sci"},{"key":"2026040708251144000_2026.04.02.26350045v1.42","doi-asserted-by":"crossref","unstructured":"Anlar, G. G. et al. Metabolomics Profiling of Stages of Coronary Artery Disease Progression. Metabolites 14 (2024).","DOI":"10.3390\/metabo14060292"},{"key":"2026040708251144000_2026.04.02.26350045v1.43","doi-asserted-by":"crossref","unstructured":"Rotbain Curovic, V. , et al. Circulating metabolomic markers in association with overall burden of microvascular complications in type 1 diabetes. BMJ Open Diabetes Res Care 12 (2024).","DOI":"10.1136\/bmjdrc-2023-003973"},{"key":"2026040708251144000_2026.04.02.26350045v1.44","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0661"},{"key":"2026040708251144000_2026.04.02.26350045v1.45","doi-asserted-by":"crossref","unstructured":"Xu, T. et al. Lipidomics Reveals Serum Specific Lipid Alterations in Diabetic Nephropathy. Front Endocrinol (Lausanne ) 12, 781417 (2021).","DOI":"10.3389\/fendo.2021.781417"},{"key":"2026040708251144000_2026.04.02.26350045v1.46","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/ATVBAHA.121.316847","article-title":"Variability of the Plasma Lipidome and Subclinical Coronary Atherosclerosis","volume":"42","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026040708251144000_2026.04.02.26350045v1.47","doi-asserted-by":"crossref","unstructured":"Ahmad, S. et al. The blood metabolome of cognitive function and brain health in middle-aged adults -influences of genes, gut microbiome, and exposome. medRxiv (2024).","DOI":"10.1101\/2024.12.16.24317793"},{"key":"2026040708251144000_2026.04.02.26350045v1.48","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1053\/j.gastro.2020.07.019","article-title":"Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis","volume":"159","year":"2020","journal-title":"Gastroenterology"},{"key":"2026040708251144000_2026.04.02.26350045v1.49","doi-asserted-by":"crossref","unstructured":"Lorenz, D. R. et al. Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults. EClinicalMedicine 31, 100697 (2021).","DOI":"10.1016\/j.eclinm.2020.100697"},{"key":"2026040708251144000_2026.04.02.26350045v1.50","doi-asserted-by":"crossref","unstructured":"Lankinen, M. , Uusitupa, M. & Schwab, U . Genes and Dietary Fatty Acids in Regulation of Fatty Acid Composition of Plasma and Erythrocyte Membranes. Nutrients 10 (2018).","DOI":"10.3390\/nu10111785"},{"key":"2026040708251144000_2026.04.02.26350045v1.51","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0696"},{"key":"2026040708251144000_2026.04.02.26350045v1.52","doi-asserted-by":"crossref","unstructured":"Ravaut, G. , L\u00e9giot, A. , Bergeron, K. F. & Mounier, C . Monounsaturated Fatty Acids in Obesity-Related Inflammation. Int J Mol Sci 22 (2020).","DOI":"10.3390\/ijms22010330"},{"key":"2026040708251144000_2026.04.02.26350045v1.53","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-pharmtox-051921-090208","article-title":"Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health","volume":"63","year":"2023","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2026040708251144000_2026.04.02.26350045v1.54","doi-asserted-by":"crossref","unstructured":"Tian, J. , Zhang, Y. & Zhao, X . The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System. Cell Mol Neurobiol 45, 25 (2025).","DOI":"10.1007\/s10571-025-01543-3"},{"key":"2026040708251144000_2026.04.02.26350045v1.55","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1038\/s41467-022-33050-0","article-title":"An online atlas of human plasma metabolite signatures of gut microbiome composition","volume":"13","year":"2022","journal-title":"Nature communications"},{"key":"2026040708251144000_2026.04.02.26350045v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0233-9"},{"key":"2026040708251144000_2026.04.02.26350045v1.57","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3389\/fphar.2019.01425","article-title":"Metabolomics and 16S rRNA Gene Sequencing Analyses of Changes in the Intestinal Flora and Biomarkers Induced by Gastrodia-Uncaria Treatment in a Rat Model of Chronic Migraine","volume":"10","year":"2019","journal-title":"Front Pharmacol"},{"key":"2026040708251144000_2026.04.02.26350045v1.58","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1038\/s41467-024-48739-7","article-title":"Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome","volume":"15","year":"2024","journal-title":"Nature communications"},{"key":"2026040708251144000_2026.04.02.26350045v1.59","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1002\/ptr.70068","article-title":"Gut Microbiota-Targeted Polyphenol Interventions: A Novel Paradigm and Synergistic Strategies for Obesity Management","volume":"39","year":"2025","journal-title":"Phytother Res"},{"key":"2026040708251144000_2026.04.02.26350045v1.60","doi-asserted-by":"crossref","unstructured":"Koppel, N. , Maini Rekdal, V. & Balskus, E. P . Chemical transformation of xenobiotics by the human gut microbiota. Science 356 (2017).","DOI":"10.1126\/science.aag2770"},{"key":"2026040708251144000_2026.04.02.26350045v1.61","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41589-023-01526-9","article-title":"Host-microbiome orchestration of the sulfated metabolome","volume":"20","year":"2024","journal-title":"Nat Chem Biol"},{"key":"2026040708251144000_2026.04.02.26350045v1.62","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000408"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.04.02.26350045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:25:25Z","timestamp":1775575525000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.04.02.26350045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":62,"URL":"https:\/\/doi.org\/10.64898\/2026.04.02.26350045","relation":{},"subject":[],"published":{"date-parts":[[2026,4,4]]},"subtype":"preprint"}}