{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:57:57Z","timestamp":1775635077404,"version":"3.50.1"},"posted":{"date-parts":[[2026,4,5]]},"group-title":"Public and Global Health","reference-count":62,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Importance<\/jats:title>\n                  <jats:p>Rural-urban disparities in chronic disease prevalence are well established; however, the extent to which individual-level socioeconomic status (SES) contributes to these disparities remains unclear.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the associations of rurality and SES with the prevalence of five most burdensome chronic diseases among adults.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>We conducted a retrospective cross-sectional study of adults across 27 Upper Midwest counties using the Expanded Rochester Epidemiology Project (E-REP) medical record data linkage system to evaluate associations between rurality, SES and chronic disease prevalence. Prevalence of clinically diagnosed asthma, diabetes, hypertension, coronary heart disease, and mood disorders was identified from International Classification of Diseases ICD9\/10 codes over a five-year period (2014-2019).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Population based<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Adults over 18 years residing in the 27 E-REP counties, excluding those missing rural-urban residence status.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Exposure<\/jats:title>\n                  <jats:p>HOUSES index, an individual-level measure of SES, served as the primary measure, while rurality based on Rural Urban Commuting Area (RUCA) codes 4-10 was the secondary measure.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Main Outcome<\/jats:title>\n                  <jats:p>Prevalence of the five clinically diagnosed chronic diseases was identified using ICD9\/10 codes from 2014\u20132019. Mixed effect logistic regression models were used and adjusted for demographics and general medical examination receipt, to assess rural-urban and SES differences for prevalence of each chronic disease.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 455,802 adults with available HOUSES index, 42.8% lived in rural areas, 53.8% were female and 87.4% were non-Hispanic White. In the unadjusted analysis, rural and urban populations showed comparable asthma and CHD prevalence, while mood disorders, hypertension, and diabetes were more common in urban areas. After adjusting for demographic factors and healthcare utilization, rural-urban differences were no longer statistically significant, whereas SES remained strongly associated with all diseases in a dose response manner (e.g., adjusted Odds Ratio for hypertension (ref: HOUSES index Q4): 1.14, 1.27, and 1.42 for HOUSES index Q3, Q2, and Q1, respectively).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions and Relevance<\/jats:title>\n                  <jats:p>Individual-level SES measured by the HOUSES index, was more strongly associated with chronic disease prevalence than rurality, supporting its integration into population health assessment and risk stratification.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.02.26350063","type":"posted-content","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:25:13Z","timestamp":1775442313000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond Rurality: Individual Socioeconomic Status and Chronic Disease Prevalence"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8373-2185","authenticated-orcid":false,"given":"Shivani","family":"Sabarish","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic Rochester, MN"},{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-2997","authenticated-orcid":false,"given":"Chung-Il","family":"Wi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic Rochester, MN"},{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison","family":"Beenken","sequence":"additional","affiliation":[{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"},{"name":"Division of Clinical Trials and Biostatistics, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Watson","sequence":"additional","affiliation":[{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"},{"name":"Division of Clinical Trials and Biostatistics, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi A.","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic Health System, Eau Claire, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabetha A.","family":"Brockman","sequence":"additional","affiliation":[{"name":"Office for Community Engagement in Research, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Prissel","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic Rochester, MN"},{"name":"Mayo Clinic Health System Research, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Anil","sequence":"additional","affiliation":[{"name":"Mankato Hospital, Administration, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trent","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Precision Population Science Lab, Mayo Clinic Rochester, MN"},{"name":"Department of Radiation Oncology, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahyr","family":"Lugo-Fagundo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Howick V","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl L.","family":"Walker-Mcgill","sequence":"additional","affiliation":[{"name":"Carolina Complete Health, Charlotte, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon H.","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-5016","authenticated-orcid":false,"given":"Pravesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic Health System, Eau Claire, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-1317","authenticated-orcid":false,"given":"Sagar B.","family":"Dugani","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanai","family":"Pongdee","sequence":"additional","affiliation":[{"name":"Section of Allergy and Immunology, Department of Medicine, Mayo Clinic Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Sosso","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy M.","family":"Foss","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Mayo Clinic Health System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathibha","family":"Varkey","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System Administration"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna D.","family":"Garovic","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic Rochester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young J.","family":"Juhn","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, 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