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We recently identified a\n                  <jats:italic>de novo<\/jats:italic>\n                  gain-of-function\n                  <jats:italic>SKAP2<\/jats:italic>\n                  mutation in an individual with T1D, leading to hyperactive integrin signaling in myeloid cells. To dissect the mechanisms by which this mutation may lead to T1D, we generated a knock-in mouse line containing the orthologous p.G153R substitution in mouse SKAP2 on the diabetes-prone nonobese diabetic (NOD) genetic background. Both female and male SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice developed accelerated T1D. The SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice also exhibited a unique spectrum of autoantibodies, leading to immune-complex nephritis. Accelerated infiltration of pancreatic islets by myeloid cells, B lymphocytes, and activated T cells was observed in SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice. Single-cell RNA sequencing demonstrated a type 1 IFN\u03b3-driven inflammatory program within the pancreatic islets of SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice. Dendritic cells from SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice demonstrated increased antigen-presenting capacity, characterized by enhanced adhesion to T cells during immune synapse formation. Macrophages and neutrophils from SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice also showed increased integrin signaling responses, with neutrophils expressing high levels of activated \u03b22 integrins on the cell surface. When backcrossed onto the C57BL\/6J genetic background, the SKAP2\n                  <jats:sup>G153R\/G153R<\/jats:sup>\n                  mice developed spontaneous autoantibody formation and exhibited accelerated autoimmunity, including nephritis, in the pristane-induced model of autoimmune disease. These findings demonstrate that dysregulation of leukocyte integrin signaling, through alterations in\n                  <jats:italic>SKAP2,<\/jats:italic>\n                  may increase the genetic risk for autoimmunity and T1D.\n                <\/jats:p>","DOI":"10.64898\/2026.04.02.716136","type":"posted-content","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:40:15Z","timestamp":1775515215000},"source":"Crossref","is-referenced-by-count":0,"title":["Gain-of-function mutation in\n                  <i>SKAP2<\/i>\n                  leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells"],"prefix":"10.64898","author":[{"given":"Courtney M.","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A."},{"name":"The Program in Immunology, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7648-8531","authenticated-orcid":false,"given":"Chester E.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Diabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A."},{"name":"Department of Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A."},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Abram","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A."},{"name":"The Program in Immunology, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumith","family":"Poojary","sequence":"additional","affiliation":[{"name":"Diabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bridge","sequence":"additional","affiliation":[{"name":"Diabetes Center, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Genetically Engineered Murine Models (GEMM) Core, Dept of Immunology and Microbiology, University of Colorado-Anschutz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Rutsch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care, and Pain Medicine, University Hospital M\u00fcnster, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. U.S.A."},{"name":"The Program in Immunology, University of California San Francisco, San Francisco, CA 94143. U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143. 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