{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:03:52Z","timestamp":1775649832535,"version":"3.50.1"},"posted":{"date-parts":[[2026,4,6]]},"group-title":"Gastroenterology","reference-count":52,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Colorectal cancer (CRC) is a leading cause of cancer-related death, with incidence rising substantially among individuals under 50 years of age. Polygenic risk scores (PRS) hold promise for identifying high-risk individuals; when combined with lifestyle factors, they substantially improve prediction accuracy compared with models based on lifestyle factors alone. However, few clinical tools currently exist that facilitate this integrated, PRS-enhanced risk assessment. To bridge this gap, we developed\n                  <jats:bold>\n                    <jats:italic>MyGeneRisk Colo<\/jats:italic>\n                  <\/jats:bold>\n                  <jats:italic>n,<\/jats:italic>\n                  a publicly accessible web portal that delivers individualized CRC risk prediction by incorporating genetic, demographic, family history, and lifestyle factors. This paper details the development of the underlying risk prediction model, the portal\u2019s architecture and data security, our reporting framework, and engagement with a community advisory panel. Designed as a user-friendly platform,\n                  <jats:italic>MyGeneRisk Colon<\/jats:italic>\n                  aims to effectively communicate personalized CRC risk profiles and educate users and healthcare providers about prevention strategies.\n                <\/jats:p>","DOI":"10.64898\/2026.04.03.26349669","type":"posted-content","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:20:16Z","timestamp":1775510416000},"source":"Crossref","is-referenced-by-count":0,"title":["MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-6847","authenticated-orcid":false,"given":"Jiayin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania Perelman School of Medicine"},{"name":"The Children\u2019s Hospital of Philadelphia"},{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Steinfelder","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conghui","family":"Qu","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minta","family":"Thomas","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushma S","family":"Thomas","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Andrews","sequence":"additional","affiliation":[{"name":"North Sound Accountable Communities of Health, Bellingham Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Augusto","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C","family":"Corley","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, California, USA"},{"name":"Department of Gastroenterology, Kaiser Permanente Medical Center, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey K","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, San Francisco, California, USA"},{"name":"Kaiser Permanente Division of Research, Oakland, California"},{"name":"Division of Gastroenterology, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja I","family":"Berndt","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Chanock","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Gignoux","sequence":"additional","affiliation":[{"name":"Colorado Center for Personalized Medicine, University of Colorado - 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