{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T12:59:05Z","timestamp":1788008345290,"version":"build-2784847793"},"posted":{"date-parts":[[2026,4,8]]},"group-title":"Neuroscience","reference-count":120,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031162","name":"Sanford Burnham Prebys Medical Discovery Institute","doi-asserted-by":"crossref","award":["S10-OD036254"],"award-info":[{"award-number":["S10-OD036254"]}],"id":[{"id":"10.13039\/100031162","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The NCI Cancer Center","award":["P30-CA030199"],"award-info":[{"award-number":["P30-CA030199"]}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["U01MH117079"],"award-info":[{"award-number":["U01MH117079"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["RF1MH128888"],"award-info":[{"award-number":["RF1MH128888"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01MH137042"],"award-info":[{"award-number":["R01MH137042"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01HG012819"],"award-info":[{"award-number":["R01HG012819"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015326","name":"NIH Common Fund","doi-asserted-by":"crossref","award":["R01AT013748"],"award-info":[{"award-number":["R01AT013748"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01tm9b530","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DISC0-14424"],"award-info":[{"award-number":["DISC0-14424"]}],"id":[{"id":"https:\/\/ror.org\/033m8b439","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DISC4-16295"],"award-info":[{"award-number":["DISC4-16295"]}],"id":[{"id":"https:\/\/ror.org\/033m8b439","id-type":"ROR","asserted-by":"publisher"}]},{"award":["EDU4-12811"],"award-info":[{"award-number":["EDU4-12811"]}],"id":[{"id":"https:\/\/ror.org\/033m8b439","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Rising Star Award"],"award-info":[{"award-number":["Rising Star Award"]}],"id":[{"id":"https:\/\/ror.org\/02prz6q96","id-type":"ROR","asserted-by":"publisher"}]},{"award":["Freeman Hrabowski Scholar"],"award-info":[{"award-number":["Freeman Hrabowski Scholar"]}],"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/02a7hjv13","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100027475","name":"Conrad Prebys Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100027475","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02xhk2825","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/003ghvj67","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Astera Institute, Jed McCaleb and James Fickel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                <jats:p>\n                  The principle that form follows function has long guided thinking in biology and architecture alike. In the nervous system, however, form does more than reflect function: neuronal morphology actively constrains input patterns, synaptic integration, and circuit wiring. During postnatal neurodevelopment, dendritic architectures are assembled and remodeled through genetically encoded programs and activities, transforming molecular programs into circuit architecture. However, dendritic morphogenesis has been difficult to quantify at scale while systematically testing how genetic variants, including neurodevelopmental disorder (NDD) risk genes, alter these structures\n                  <jats:italic>in vivo<\/jats:italic>\n                  . We developed Perturb-CLEAR, which integrates pooled CRISPR screening and whole-mount imaging to quantify brain-wide cytoarchitecture, and paired it with Perturb-seq to link structural phenotypes to transcriptomic changes. Applying Perturb-CLEAR to the developing mouse cortex revealed morphogenesis trajectories accompanied by transcriptomic dynamics. Moreover, systematic perturbation of NDD risk genes uncovered gene-specific multimodal phenotypes.\n                  <jats:italic>Adnp<\/jats:italic>\n                  perturbation remodels basal dendrites in L4\/5 IT (intratelencephalic) neurons but not other dendritic compartments or cell types, alongside consistent transcriptional shifts. Combined morphology and transcriptome analyses link NDD risk genes to concordant multimodal cellular phenotypes in the developing brain, highlighting diverse paths of perturbation effect propagation across modalities.\n                <\/jats:p>","DOI":"10.64898\/2026.04.06.716787","type":"posted-content","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:20:12Z","timestamp":1775715612000},"source":"Crossref","is-referenced-by-count":2,"title":["Concordant transcriptional and morphological remodeling revealed by\n                  <i>in vivo<\/i>\n                  Perturb-CLEAR"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-5078","authenticated-orcid":false,"given":"Boli","family":"Wu","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean K.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-4763","authenticated-orcid":false,"given":"Jiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-6974","authenticated-orcid":false,"given":"Masood A.","family":"Akram","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-7236","authenticated-orcid":false,"given":"Chang Sin","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-6724","authenticated-orcid":false,"given":"Xinhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Mendez","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Patel","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Chau","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Burciu","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay","family":"Dayal","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thokozile","family":"Nyasulu","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan","family":"Huynh","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace S.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-7935","authenticated-orcid":false,"given":"X. William","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-3598","authenticated-orcid":false,"given":"Joshua Z.","family":"Levin","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-992X","authenticated-orcid":false,"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Chevy Chase, MD, USA"},{"name":"Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026041019201597000_2026.04.06.716787v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.031"},{"key":"2026041019201597000_2026.04.06.716787v1.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg7285"},{"key":"2026041019201597000_2026.04.06.716787v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature07709"},{"key":"2026041019201597000_2026.04.06.716787v1.4","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00177"},{"key":"2026041019201597000_2026.04.06.716787v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01253-9"},{"key":"2026041019201597000_2026.04.06.716787v1.6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135703"},{"key":"2026041019201597000_2026.04.06.716787v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2286"},{"key":"2026041019201597000_2026.04.06.716787v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00182-3"},{"key":"2026041019201597000_2026.04.06.716787v1.9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125631"},{"key":"2026041019201597000_2026.04.06.716787v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2699"},{"key":"2026041019201597000_2026.04.06.716787v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2836"},{"key":"2026041019201597000_2026.04.06.716787v1.12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013038"},{"key":"2026041019201597000_2026.04.06.716787v1.13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013020"},{"key":"2026041019201597000_2026.04.06.716787v1.14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001727"},{"key":"2026041019201597000_2026.04.06.716787v1.15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110817"},{"key":"2026041019201597000_2026.04.06.716787v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2023.102214"},{"key":"2026041019201597000_2026.04.06.716787v1.17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071746"},{"key":"2026041019201597000_2026.04.06.716787v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3445"},{"key":"2026041019201597000_2026.04.06.716787v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.057"},{"key":"2026041019201597000_2026.04.06.716787v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2907-3"},{"key":"2026041019201597000_2026.04.06.716787v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03941-1"},{"key":"2026041019201597000_2026.04.06.716787v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03813-8"},{"key":"2026041019201597000_2026.04.06.716787v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00576-7"},{"key":"2026041019201597000_2026.04.06.716787v1.24","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-120823-125811"},{"key":"2026041019201597000_2026.04.06.716787v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.112"},{"key":"2026041019201597000_2026.04.06.716787v1.26","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182130c54"},{"key":"2026041019201597000_2026.04.06.716787v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.017"},{"key":"2026041019201597000_2026.04.06.716787v1.28","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00024"},{"key":"2026041019201597000_2026.04.06.716787v1.29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6063"},{"key":"2026041019201597000_2026.04.06.716787v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06570-y"},{"key":"2026041019201597000_2026.04.06.716787v1.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.050"},{"key":"2026041019201597000_2026.04.06.716787v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00069-4"},{"key":"2026041019201597000_2026.04.06.716787v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00515-3"},{"key":"2026041019201597000_2026.04.06.716787v1.34","doi-asserted-by":"publisher","DOI":"10.1038\/nature06293"},{"key":"2026041019201597000_2026.04.06.716787v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.005"},{"key":"2026041019201597000_2026.04.06.716787v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.042"},{"key":"2026041019201597000_2026.04.06.716787v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.07.019"},{"key":"2026041019201597000_2026.04.06.716787v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01339-y"},{"key":"2026041019201597000_2026.04.06.716787v1.39","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj9198"},{"key":"2026041019201597000_2026.04.06.716787v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03970-w"},{"key":"2026041019201597000_2026.04.06.716787v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02085-z"},{"key":"2026041019201597000_2026.04.06.716787v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06812-z"},{"key":"2026041019201597000_2026.04.06.716787v1.43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062111-150343"},{"key":"2026041019201597000_2026.04.06.716787v1.44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-100520-012117"},{"key":"2026041019201597000_2026.04.06.716787v1.45","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad371"},{"key":"2026041019201597000_2026.04.06.716787v1.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.09.041"},{"key":"2026041019201597000_2026.04.06.716787v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0417-0"},{"key":"2026041019201597000_2026.04.06.716787v1.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01041-5"},{"key":"2026041019201597000_2026.04.06.716787v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-025-02621-6"},{"key":"2026041019201597000_2026.04.06.716787v1.50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5222-10.2011"},{"key":"2026041019201597000_2026.04.06.716787v1.51","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2011.00005"},{"key":"2026041019201597000_2026.04.06.716787v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41661-9"},{"key":"2026041019201597000_2026.04.06.716787v1.53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2910-19.2020"},{"key":"2026041019201597000_2026.04.06.716787v1.54","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac467"},{"key":"2026041019201597000_2026.04.06.716787v1.55","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22728"},{"key":"2026041019201597000_2026.04.06.716787v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.02.015"},{"key":"2026041019201597000_2026.04.06.716787v1.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00360-9"},{"key":"2026041019201597000_2026.04.06.716787v1.58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6042-10.2011"},{"key":"2026041019201597000_2026.04.06.716787v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09644-1"},{"key":"2026041019201597000_2026.04.06.716787v1.60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003176"},{"key":"2026041019201597000_2026.04.06.716787v1.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2832-5"},{"key":"2026041019201597000_2026.04.06.716787v1.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.036"},{"key":"2026041019201597000_2026.04.06.716787v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01104-0"},{"key":"2026041019201597000_2026.04.06.716787v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04556-w"},{"key":"2026041019201597000_2026.04.06.716787v1.65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3793-07.2007"},{"key":"2026041019201597000_2026.04.06.716787v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.045"},{"key":"2026041019201597000_2026.04.06.716787v1.67","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1367-20.2020"},{"key":"2026041019201597000_2026.04.06.716787v1.68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127671"},{"key":"2026041019201597000_2026.04.06.716787v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01939-3"},{"key":"2026041019201597000_2026.04.06.716787v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0268-0"},{"key":"2026041019201597000_2026.04.06.716787v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.07.007"},{"key":"2026041019201597000_2026.04.06.716787v1.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115384"},{"key":"2026041019201597000_2026.04.06.716787v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.116"},{"key":"2026041019201597000_2026.04.06.716787v1.74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013494107"},{"key":"2026041019201597000_2026.04.06.716787v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.029"},{"key":"2026041019201597000_2026.04.06.716787v1.76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3567-14.2015"},{"key":"2026041019201597000_2026.04.06.716787v1.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2026.114700"},{"key":"2026041019201597000_2026.04.06.716787v1.78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087360"},{"key":"2026041019201597000_2026.04.06.716787v1.79","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02415-1"},{"key":"2026041019201597000_2026.04.06.716787v1.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115311"},{"key":"2026041019201597000_2026.04.06.716787v1.81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716322115"},{"key":"2026041019201597000_2026.04.06.716787v1.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113859118"},{"key":"2026041019201597000_2026.04.06.716787v1.83","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr7691"},{"key":"2026041019201597000_2026.04.06.716787v1.84","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0426-0"},{"key":"2026041019201597000_2026.04.06.716787v1.85","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1726"},{"key":"2026041019201597000_2026.04.06.716787v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01154-0"},{"key":"2026041019201597000_2026.04.06.716787v1.87","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98199"},{"key":"2026041019201597000_2026.04.06.716787v1.88","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac152"},{"key":"2026041019201597000_2026.04.06.716787v1.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.09.018"},{"key":"2026041019201597000_2026.04.06.716787v1.90","doi-asserted-by":"publisher","DOI":"10.1002\/aur.70069"},{"key":"2026041019201597000_2026.04.06.716787v1.91","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0263-5"},{"key":"2026041019201597000_2026.04.06.716787v1.92","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15178"},{"key":"2026041019201597000_2026.04.06.716787v1.93","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.016"},{"key":"2026041019201597000_2026.04.06.716787v1.94","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51090-3"},{"key":"2026041019201597000_2026.04.06.716787v1.95","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3365"},{"key":"2026041019201597000_2026.04.06.716787v1.96","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1037"},{"key":"2026041019201597000_2026.04.06.716787v1.97","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4281"},{"key":"2026041019201597000_2026.04.06.716787v1.98","doi-asserted-by":"publisher","DOI":"10.32614\/CRAN.package.dynamicTreeCut"},{"key":"2026041019201597000_2026.04.06.716787v1.99","unstructured":"R: A language and environment for statistical computing. R Foundation for Statistical Computing (Vienna, Austria, 2018)."},{"key":"2026041019201597000_2026.04.06.716787v1.100","doi-asserted-by":"publisher","DOI":"10.32614\/CRAN.package.e1071"},{"key":"2026041019201597000_2026.04.06.716787v1.101","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"2026041019201597000_2026.04.06.716787v1.102","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.01.458620"},{"key":"2026041019201597000_2026.04.06.716787v1.103","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"2026041019201597000_2026.04.06.716787v1.104","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"2026041019201597000_2026.04.06.716787v1.105","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026041019201597000_2026.04.06.716787v1.106","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"2026041019201597000_2026.04.06.716787v1.107","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1071"},{"key":"2026041019201597000_2026.04.06.716787v1.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.002"},{"key":"2026041019201597000_2026.04.06.716787v1.109","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"2026041019201597000_2026.04.06.716787v1.110","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.21.537881"},{"key":"2026041019201597000_2026.04.06.716787v1.111","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz698"},{"key":"2026041019201597000_2026.04.06.716787v1.112","doi-asserted-by":"publisher","DOI":"10.64898\/2026.03.06.710160"},{"key":"2026041019201597000_2026.04.06.716787v1.113","doi-asserted-by":"publisher","DOI":"10.18129\/B9.bioc.HDF5Array"},{"key":"2026041019201597000_2026.04.06.716787v1.114","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa1009"},{"key":"2026041019201597000_2026.04.06.716787v1.115","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"2026041019201597000_2026.04.06.716787v1.116","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn209"},{"key":"2026041019201597000_2026.04.06.716787v1.117","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02169-3"},{"key":"2026041019201597000_2026.04.06.716787v1.118","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"2026041019201597000_2026.04.06.716787v1.119","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"2026041019201597000_2026.04.06.716787v1.120","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-02144-y"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.04.06.716787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:20:27Z","timestamp":1775874027000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.04.06.716787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":120,"URL":"https:\/\/doi.org\/10.64898\/2026.04.06.716787","relation":{},"subject":[],"published":{"date-parts":[[2026,4,8]]},"subtype":"preprint"}}