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FDG-PET studies published through July 2025 were identified from MEDLINE, Embase, PsycINFO, Scopus, and Cochrane databases. Studies comparing adults with late-onset neurodegenerative disease to healthy controls and reporting whole-brain coordinate findings were included. Activation likelihood estimation meta-analyses were conducted using extracted coordinates of hypo- and hypermetabolism. A total of 130 studies were included, comprising 5,298 individuals with A\n                  <jats:sup>2<\/jats:sup>\n                  ND and 3,499 controls. Meta-analyses revealed dysregulated glucose metabolism as a unifying feature across A\n                  <jats:sup>2<\/jats:sup>\n                  NDs and included both hypo- and hypermetabolic patterns. However, the spatial distribution of metabolic abnormalities differed across diseases, with each disease demonstrating distinct neuroanatomical patterns associated with disease-relevant functional systems. While hypometabolism primarily in the cortex remains a primary focus in neurodegenerative disease research due to functional relevance, hypermetabolism was also consistently identified across all three diseases, predominantly in subcortical, limbic, and cerebellar structures. This dissociation, with hypermetabolic regions localized to structures with known functional connectivity to affected cortical networks, suggests compensatory upregulation as a plausible interpretation, though alternative mechanisms, including neuroinflammation, cannot be excluded.\n                <\/jats:p>","DOI":"10.64898\/2026.04.07.26350339","type":"posted-content","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:40:32Z","timestamp":1775695232000},"source":"Crossref","is-referenced-by-count":1,"title":["Meta-analysis of glucose metabolism across Alzheimer\u2019s, Parkinson\u2019s and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-6727","authenticated-orcid":false,"given":"Adam C.","family":"Raikes","sequence":"first","affiliation":[{"name":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Garza","sequence":"additional","affiliation":[{"name":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-5489","authenticated-orcid":false,"given":"Coco","family":"Tirambulo","sequence":"additional","affiliation":[{"name":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA"},{"name":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-6163","authenticated-orcid":false,"given":"Angela N.","family":"Murrell","sequence":"additional","affiliation":[{"name":"Health Sciences Library, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-772X","authenticated-orcid":false,"given":"Roberta Diaz","family":"Brinton","sequence":"additional","affiliation":[{"name":"Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, USA"},{"name":"Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA"},{"name":"Department of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026090201101621000_2026.04.07.26350339v2.1","unstructured":"Clarke, D. 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