{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:01:35Z","timestamp":1776391295597,"version":"3.51.2"},"posted":{"date-parts":[[2026,4,13]]},"group-title":"Neuroscience","reference-count":26,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Abnormal beta-band activity (13-30 Hz) within the cortico-basal ganglia network is a hallmark of Parkinson\u2019s disease (PD) and is closely linked to motor impairment. Pathological beta activity in the subthalamic nucleus (STN) occurs predominantly as brief, high-amplitude bursts rather than continuous oscillations. Although beta-band coherence between the STN and cortex increases during bursts, it remains unclear whether cortico-STN beta coupling persists outside these bursts. Using intraoperative STN local field potentials and simultaneous cortical electrocorticography from seven patients undergoing deep brain stimulation implantation surgery, cortico-STN beta coupling during burst and non-burst epochs was compared. Coupling was assessed using magnitude-squared coherence and the debiased weighted phase lag index (dwPLI) and compared against surrogate distributions generated by circular time-shifting. Both coupling metrics were significantly elevated during burst epochs relative to non-burst periods. During non-burst epochs, coupling collapsed to surrogate levels, indicating no evidence of sustained synchronization. Time-resolved analyses further demonstrated that elevated coupling was confined to burst epochs. Although a subset of motor cortical contacts exhibited elevated baseline coherence, coupling was less evident using dwPLI. These findings suggest that pathological cortico-STN beta coupling in PD is preferentially expressed during beta bursts rather than sustained across non-burst epochs, with implications for adaptive neuromodulation strategies.<\/jats:p>","DOI":"10.64898\/2026.04.09.717378","type":"posted-content","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:55:16Z","timestamp":1776095716000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathological cortico-STN beta coupling in Parkinson\u2019s disease is confined to beta bursts"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-0281","authenticated-orcid":false,"given":"Christopher A.","family":"Beaudoin","sequence":"first","affiliation":[{"name":"School of Medicine and Biomedical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew 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