{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:51:25Z","timestamp":1776390685901,"version":"3.51.2"},"posted":{"date-parts":[[2026,4,13]]},"group-title":"Psychiatry and Clinical Psychology","reference-count":25,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an effective treatment for severe obsessive-compulsive disorder (OCD). Identifying brain readouts of positive response may guide further DBS optimization.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured local field potential (LFP) changes from bilateral DBS leads in 10 OCD patients implanted at a uniform tractographic network target derived from prior DBS responders. We consistently stimulated dorsal lead contacts in the ALIC white matter, while recording LFP from the ventral lead contacts in grey matter of the anterior globus pallidus externus (GPe), a key node in the basal ganglia non-motor indirect pathway.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After six months of DBS, OCD symptoms decreased on average by 40% across subjects, along with a significant decrease in alpha activity across both hemispheres. Only one patient did not have an improvement of symptoms, and this was also the only patient to never exhibit an alpha decrease in either hemisphere.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest that therapeutic ALIC DBS coincides with a stable decrease in limbic-cognitive GPe alpha power, which should be further investigated as a potential biomarker of sustained response.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.10.26350428","type":"posted-content","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:50:12Z","timestamp":1776113412000},"source":"Crossref","is-referenced-by-count":0,"title":["Globus pallidus externus (GPe) alpha band activity decreases after deep brain stimulation in clinically responsive obsessive-compulsive disorder patients"],"prefix":"10.64898","author":[{"given":"Zarghona","family":"Imtiaz","sequence":"first","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, New York University Grossman School of Medicine, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian H.","family":"Kopell","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Olson","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Saez","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Neul","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen S.","family":"Mayberg","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Sueng","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Radiology, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison C.","family":"Waters","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Figee","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY"},{"name":"Department of Psychiatry, New York University Grossman School of Medicine, 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