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Here, we present a canine dorsal root ganglion (DRG) cell atlas generated from six donors, representing five breeds, both sexes, and three spinal segments. Our dataset comprises 3,026 neurons and 11,734 non-neuronal cells and resolves 15 neuronal subtypes that map cleanly onto A- and C-fiber classes. We further identify eight major non-neuronal subtypes, including glial, vascular, and immune populations and characterize neuronal and non-neuronal expression of physiologically relevant neuropeptides, receptors, and ion channels. We identify region-specific differences in subtype composition between lumbar and sacral DRGs, with transcriptional programs suggestive of enhanced tactile-associated signaling in lumbar DRGs and heightened nociception-associated signaling in sacral DRGs. Cross-species comparisons reveal that canine DRG subtypes are broadly conserved with human and mouse, while also exhibiting canine-specific and canine\u2013human shared molecular features relevant for translation. Together, this atlas serves as a valuable resource for understanding canine sensory neurobiology, comparing DRG organization across mammals, and leveraging dogs as a translational model for pain research and therapeutic development.<\/jats:p>","DOI":"10.64898\/2026.04.14.718477","type":"posted-content","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:40:18Z","timestamp":1776447618000},"source":"Crossref","is-referenced-by-count":1,"title":["Translational insights into canine dorsal root ganglia cell types using cross-species comparisons"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-0921","authenticated-orcid":false,"given":"Leanne","family":"Jankelunas","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3260-600X","authenticated-orcid":false,"given":"Shamsuddin A.","family":"Bhuiyan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-4989","authenticated-orcid":false,"given":"Hannah J.","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-0615","authenticated-orcid":false,"given":"Thomas","family":"Cecere","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-8010","authenticated-orcid":false,"given":"Andrea","family":"Bertke","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-7076","authenticated-orcid":false,"given":"John H.","family":"Rossmeisl","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"},{"name":"Veterinary and Comparative Neuro-oncology Laboratory, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-2101","authenticated-orcid":false,"given":"William","family":"Renthal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-1818","authenticated-orcid":false,"given":"Rell L.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026042509451964000_2026.04.14.718477v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.051"},{"key":"2026042509451964000_2026.04.14.718477v2.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.060"},{"issue":"1","key":"2026042509451964000_2026.04.14.718477v2.3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2460\/ajvr.1988.49.01.115","article-title":"Spinal nerve root origins of the cutaneous nerves of the canine pelvic limb","volume":"49","year":"1988","journal-title":"American Journal of Veterinary Research"},{"key":"2026042509451964000_2026.04.14.718477v2.4","doi-asserted-by":"publisher","DOI":"10.1038\/nature05910"},{"key":"2026042509451964000_2026.04.14.718477v2.5","doi-asserted-by":"crossref","unstructured":"Bhuiyan SA , Nagi SS , Sankaranarayanan I , Semizoglou E , Usoskin D , Yang L , Yu H , Arendt-Tranholm A , Bertels Z , Bhatia P , Bouchatta O , Boyer K , Cervantes A , Chalif J , Chintalapudi H , Cicalo A , Copits B , Cronin C , Curatolo M , \u2026, Network NIHPHP . 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