{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:38:35Z","timestamp":1776656315237,"version":"3.51.2"},"posted":{"date-parts":[[2026,4,16]]},"group-title":"Neuroscience","reference-count":71,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Cerebrospinal fluid-contacting neurons (CSF-cNs) are mechanosensory cells in the spinal cord that detect compression and regulate locomotion, posture, and morphogenesis. Although CSF-cNs respond to changes in pH, neurotransmitters and metabolites, their chemosensory repertoire is not fully understood. Using hybridization chain reaction, we investigated the distribution of expression of chemoreceptors in CSF-cNs and neighboring cells in the spinal cord. We found that CSF-cNs express receptors for glutamate (\n                  <jats:italic>grm2<\/jats:italic>\n                  ), somatostatin (\n                  <jats:italic>sstr2<\/jats:italic>\n                  ) and low-density lipoprotein (LDL) (ldlrad2), indicating roles in detecting glutamate, somatostatin and LDL in the CSF. High LDL receptor expression in CSF-contacting cells suggests CSF lipid capture. Most receptors were enriched but not exclusive to CSF-cNs and also appeared in ependymal radial glial cells. Our findings indicate multiple chemosensory pathways can sustain long-distance communication between neurons and glia through the cerebrospinal fluid.\n                <\/jats:p>","DOI":"10.64898\/2026.04.14.718607","type":"posted-content","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:20:16Z","timestamp":1776352816000},"source":"Crossref","is-referenced-by-count":0,"title":["Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord"],"prefix":"10.64898","author":[{"given":"Emily","family":"Verran","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (Institut du Cerveau, ICM), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1127, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7225, Assistance Publique\u2013H\u00f4pitaux de Paris, Campus Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Moizan","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (Institut du Cerveau, ICM), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1127, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7225, Assistance Publique\u2013H\u00f4pitaux de Paris, Campus Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loeva","family":"Tocquer","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (Institut du Cerveau, ICM), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1127, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7225, Assistance Publique\u2013H\u00f4pitaux de Paris, Campus Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng B.","family":"Quan","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (Institut du Cerveau, ICM), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1127, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7225, Assistance Publique\u2013H\u00f4pitaux de Paris, Campus Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-4975","authenticated-orcid":false,"given":"Claire","family":"Wyart","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Paris Brain Institute (Institut du Cerveau, ICM), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1127, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 7225, Assistance Publique\u2013H\u00f4pitaux de Paris, Campus 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