{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:22:38Z","timestamp":1785421358043,"version":"3.56.0"},"posted":{"date-parts":[[2026,4,20]]},"group-title":"Neuroscience","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"funder":[{"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The superior colliculus integrates retinal input to drive rapid, adaptive visual behavior, yet how the functional diversity of retinal ganglion cell types is represented in superior colliculus remains poorly understood. Using chronic two-photon calcium imaging of retinal ganglion cell axonal boutons in awake mice, we recorded over 200,000 boutons across superficial superior colliculus layers \u2014 a scale that enabled systematic comparison with large-scale\n                  <jats:italic>ex vivo<\/jats:italic>\n                  retinal datasets. This revealed that the superior colliculus receives a near-complete sampling of retinal ganglion cell functional diversity. Functionally distinct response types were organized in systematic laminar gradients: not only response properties such as direction selectivity and contrast suppression, but retinal response types themselves varied systematically with depth. To probe how this organized input encodes natural scenes, we trained a \u201cdigital twin\u201d deep network model on natural movie responses and validated its generalization to parametric stimuli, including cell type identification. Leveraging this model to generate predicted responses to looming stimuli, we identify a discrete subset of retinal response types tuned for collision detection at low angular thresholds \u2014 a specialization embedded within a broader, non-specialized retinal population. The digital twin is made publicly available as a community resource. Together, these findings provide a comprehensive functional map of retinal drive to the superior colliculus and an\n                  <jats:italic>in silico<\/jats:italic>\n                  platform for linking retinal cell types to behaviorally relevant superior colliculus computations.\n                <\/jats:p>","DOI":"10.64898\/2026.04.15.718783","type":"posted-content","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:59:51Z","timestamp":1776941991000},"source":"Crossref","is-referenced-by-count":0,"title":["The functional organization of retinal input to the mouse superior colliculus"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9944-2180","authenticated-orcid":false,"given":"Yongrong","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, USA"},{"name":"Stanford Bio-X, Stanford University, USA"},{"name":"Wu Tsai Neurosciences Institute, 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