{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:40:12Z","timestamp":1777146012864,"version":"3.51.4"},"posted":{"date-parts":[[2026,4,22]]},"group-title":"Cardiovascular Medicine","reference-count":24,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA) is a common comorbidity in heart failure (HF) patients with prevalence increasing as HF severity worsens. While CPAP\/BiPAP has been shown to reduce disease burden and mortality in the general HF population, it is unclear whether these benefits extend to patients with left ventricular assist devices (LVADs). We sought to determine whether OSA affects long-term survival in newly implanted LVAD patients and whether CPAP\/BiPAP treatment confers mortality benefits.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-center retrospective study included patients who underwent LVAD implantation between January 2007 and February 2022. Recipients were stratified by OSA status (OSA vs No-OSA), and those with OSA were further categorized based on CPAP\/BiPAP compliance. Comparative statistics and Kaplan\u2013Meier survival analyses were performed, with log-rank tests used to compare groups and assess survival differences. A Cox proportional hazards model was conducted to evaluate the association between risk factors and survival among patients with OSA and No-OSA.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Before LVAD implantation, patients with OSA had higher body mass index, hypertension, and a higher rate of implantable cardioverter-defibrillator placement than those without OSA. OSA was not associated with increased postoperative complications. Although survival did not differ significantly between OSA and No-OSA patients (p=0.33), CPAP\/BiPAP-compliant OSA patients had significantly better survival than noncompliant patients (p=0.0099).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LVAD patients with OSA who consistently use CPAP\/BiPAP have better survival than those who do not. CPAP\/BiPAP is a simple, low-risk treatment that can reduce mortality in this population. Therefore, increased perioperative screening for OSA should be considered for patients receiving LVADs. Multicenter studies are needed to confirm our findings further.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.20.26351345","type":"posted-content","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:40:24Z","timestamp":1776876024000},"source":"Crossref","is-referenced-by-count":0,"title":["CPAP\/BiPAP Compliance Improves Survival in LVAD Recipients with Obstructive Sleep Apnea"],"prefix":"10.64898","author":[{"given":"Jason","family":"Carlquist","sequence":"first","affiliation":[{"name":"The Ohio State University College of Medicine, Department of Internal Medicine, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-3026","authenticated-orcid":false,"given":"Shane S.","family":"Scott","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH"},{"name":"Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH"},{"name":"Bob and Corrinne Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-7235","authenticated-orcid":false,"given":"Jonathan C.","family":"Wright","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine, Department of Internal Medicine, Columbus, OH"},{"name":"Bob and Corrinne Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Jianing","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-5997","authenticated-orcid":false,"given":"Nahush A.","family":"Mokadam","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of surgery, The Ohio State University Wexner Medical Center, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-3638","authenticated-orcid":false,"given":"Bryan A.","family":"Whitson","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of surgery, The Ohio State University Wexner Medical Center, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakima A.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine, Department of Internal Medicine, Columbus, OH"},{"name":"Dorothy M. 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