{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:39:37Z","timestamp":1777145977919,"version":"3.51.4"},"posted":{"date-parts":[[2026,4,22]]},"group-title":"Genetic and Genomic Medicine","reference-count":49,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Pancreatic cancer disproportionately affects Black individuals in the United States, but they have limited representation in genetic studies of pancreatic ductal adenocarcinoma (PDAC). To address this gap, we performed admixture mapping and genome-wide association analysis (GWAS) in genetically inferred African ancestry individuals (1,030 cases and 889 controls). Admixture mapping identified three regions with a significantly higher proportion of African ancestry in cases compared to controls (5q33.3, 10p1, 22q12.3). GWAS identified a genome-wide significant association at 5p15.33 (\n                  <jats:italic>CLPTM1L<\/jats:italic>\n                  , rs383009:T&gt;C, T Allele Frequency=0.51, OR:1.45, P value=1.24\u00d710\n                  <jats:sup>-8<\/jats:sup>\n                  ), a locus previously associated with PDAC. Known loci at 5p15.33, 7q32.3, 8q24.21 and 7q25.1 also replicated (P value &lt;0.01). Multi-ancestral fine-mapping identified two potential causal SNPs (rs3830069 and rs2735940) at 5p15.33. Collectively these findings identified novel PDAC risk loci and expanded our understanding of this deadly cancer in underrepresented populations, emphasizing the multifactorial nature of PDAC risk including inherited genetic and non-genetic factors.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Statement of Significance<\/jats:title>\n                  <jats:p>To understand how genetic variation contributes to PDAC risk in Black people in North American, we studied individuals of genetically-inferred African ancestry. We identified novel risk loci and differences in the contribution of known loci. This demonstrates that ancestry-informed genetic analyses improve our understanding of PDAC risk and enhances discovery.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.21.26351329","type":"posted-content","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:30:39Z","timestamp":1776936639000},"source":"Crossref","is-referenced-by-count":0,"title":["Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals"],"prefix":"10.64898","author":[{"given":"Candelaria","family":"Vergara","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanmo","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-9434","authenticated-orcid":false,"given":"Jun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McKean","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn E.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel O.","family":"Antwi","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, Jacksonville, FL, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan A","family":"Arslan","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology and Population Health, NYU Grossman School of Medicine, NYU Perlmutter Comprehensive Cancer Center, New York, NY, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige M.","family":"Bracci","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics,, University of California San Francisco, San Francisco, CA, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center,, New York, NY, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute,, Sinai Health System and University of Toronto,, Toronto, Ontario, Canada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine","family":"Genkinger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Columbia University, New York, NY, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A","family":"Haiman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, Houston, TX, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayjean J.","family":"Hung","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute,, Sinai Health System and University of Toronto,, Toronto, Ontario, Canada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Huff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Kooperberg","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fay","family":"Kastrinos","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA,"},{"name":"Herbert Irving 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