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Soluble antigen (sAg) induces tolerance, whereas patterned antigen display on virus-like particles (pAg) triggers robust B cell responses that can proceed without T cell help. Here, we show how this divergence arises early in BCR signaling. Unlike sAg, pAg can bypass a Lyn-dependent negative feedback loop to trigger digital signaling, such that ultra-low concentrations of pAg produce strong and sustained Ca\n                  <jats:sup>2+<\/jats:sup>\n                  responses. Surprisingly, pAg drives maximal nuclear NF-\u03baB but limited NFAT, whereas sAg does the opposite, reflecting differential production of diacylglycerol. Consequently, sAg induced an NFAT-dependent anergy program, whereas pAg evaded this state and instead engaged a cMyc-driven program that partially resembles a TLR-dependent danger response. Our findings reveal how proximal signaling directs distinct transcriptional fate to enable immunogenic B cell responses to virus-like antigen display.\n                <\/jats:p>","DOI":"10.64898\/2026.04.23.720482","type":"posted-content","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:40:21Z","timestamp":1777081221000},"source":"Crossref","is-referenced-by-count":0,"title":["Virus-like antigen display delivers a stand\u2013alone danger signal through the BCR that circumvents tolerance"],"prefix":"10.64898","author":[{"given":"Julianne B.","family":"Riggs","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Rosalind Russell and Ephraim P. 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Huron Street, University of Michigan, Ann Arbor, Michigan 48104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-6288","authenticated-orcid":false,"given":"Wei-Yun","family":"Wholey","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, 1007 E. Huron Street, University of Michigan, Ann Arbor, Michigan 48104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Libang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Rosalind Russell and Ephraim P. 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