{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:35:19Z","timestamp":1777865719147,"version":"3.51.4"},"posted":{"date-parts":[[2026,4,27]]},"group-title":"Oncology","reference-count":29,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.medrxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,4,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>PURPOSE<\/jats:title>\n                  <jats:p>Bispecific antibodies (BsAbs) represent a major advancement in the management of relapsed\/refractory multiple myeloma (RRMM), offering high response rates even in heavily pretreated patients. However, their use presents operational, safety, and supportive care complexities that require coordinated care teams, and evolving infrastructure. This manuscript summarizes best practice recommendations for adverse event (AE) management, outpatient operational models, referral pathways, and emerging strategies to optimize long-term tolerability.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Medlive\u2014A PlatformQ Health Brand conducted qualitative interviews of academic and community-based clinicians. Discussions focused on BsAb implementation, patient selection and counseling, and AE management. Experts provided recommendations on team-based protocols, transitions of care, and inpatient versus outpatient considerations.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Ten hematologists\/oncologists (academic n=4; community n=6) described practice patterns, barriers, and perspectives on BsAb use. BsAbs were consistently regarded as highly effective across multiple lines of therapy, particularly for patients without alternatives. Cytokine release syndrome (CRS) was the most common acute toxicity, generally low grade and managed effectively with early tocilizumab, including prophylactic use in outpatient settings. Immune effector cell-associated neurotoxicity syndrome (ICANS) was rare, mild, and best mitigated through early recognition and caregiver support. Infections, largely from BCMA-associated hypogammaglobulinemia, frequently interrupted therapy, necessitating antiviral prophylaxis, pneumocystis jirovecii pneumonia (PJP) prophylaxis, and intravenous immunoglobulin (IVIG). Outpatient step-up dosing is expanding, supported by prophylactic strategies and academic-community collaboration. Timely referral was emphasized to preserving eligibility. Major outpatient challenges included sequencing, infrastructure readiness, and standardized caregiver and staff education.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Effective community implementation of BsAbs requires multidisciplinary coordination, standardized AE protocols, infection prevention, and infrastructure to support monitoring, referrals, and equitable access. These measures are critical to ensure safe, sustainable integration of bispecific therapies and to optimize patient outcomes.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.04.24.26350878","type":"posted-content","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:13:05Z","timestamp":1777327985000},"source":"Crossref","is-referenced-by-count":0,"title":["Practical Management of Adverse Events Associated with Bispecific Antibodies for the Treatment of Multiple Myeloma: A Qualitative Interview Study"],"prefix":"10.64898","author":[{"given":"Tisheeka R.","family":"Graham","sequence":"first","affiliation":[{"name":"Medlive-A PlatformQ Health Brand, Needham, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"White","sequence":"additional","affiliation":[{"name":"Medlive-A PlatformQ Health Brand, Needham, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Blue","sequence":"additional","affiliation":[{"name":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Hartley-Brown","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley D.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Intermountain Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Cancer Care Associates of York, York, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Joseph","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany","family":"Keruakous","sequence":"additional","affiliation":[{"name":"Augusta University, Augusta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Pan","sequence":"additional","affiliation":[{"name":"University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Georgia Cancer Specialists, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Bayhealth Hematology\/Oncology Associates, Dover, DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attaya","family":"Suvannasankha","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026043000201975000_2026.04.24.26350878v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0065-8"},{"key":"2026043000201975000_2026.04.24.26350878v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00359-2"},{"key":"2026043000201975000_2026.04.24.26350878v1.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400712"},{"key":"2026043000201975000_2026.04.24.26350878v1.4","unstructured":"National Cancer Institute. 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