{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:21:31Z","timestamp":1785435691177,"version":"3.56.0"},"posted":{"date-parts":[[2026,4,29]]},"group-title":"Neuroscience","reference-count":0,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R21AG065819"],"award-info":[{"award-number":["R21AG065819"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AWD09459"],"award-info":[{"award-number":["AWD09459"]}],"id":[{"id":"https:\/\/ror.org\/02y3ad647","id-type":"ROR","asserted-by":"publisher"}]},{"award":["DMR-1644779"],"award-info":[{"award-number":["DMR-1644779"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,15]]},"abstract":"<jats:p>Temporal dynamics in functional connectomes provide a physiologically grounded signature of \u2032hidden\u2032 pathologies during preclinical stages of Alzheimer\u2032s disease (AD). We evaluated the effect of beta-amyloid (A\u03b2) on dynamic functional connectomes in transgenic mice and human subjects. Functional magnetic resonance images (fMRI) were collected in two strains of A\u03b2 mice. fMRI-derived connectomes were segmented into discrete states using a hidden Markov model, and network strength, efficiency, and transitivity were analyzed per state. Human fMRI-derived connectome measures were analyzed across 3 states. Static network measures were significantly different between A\u03b2 mice and controls, the former having high values for strength, efficiency and clustering coefficient in anterior cingulate, hippocampus, and retrosplenium. Dynamic network measures were stable within-states in A\u03b2 mice. Similarly, human subjects with high A\u03b2 had high node strength in precuneus and temporoparietal areas compared to low A\u03b2. Conversely, high A\u03b2 was associated with high switch rates, high fractional occupancy, and state dwell times. Also, global strength, efficiency, and transitivity were less stable within states in the high A\u03b2 group. Our results indicate that static, but not dynamic, connectome strength, efficiency, and network integration are increased in A\u03b2 mice, while dynamic network states appear less stable in human functional connectomes. This data supports a dissociable, species-specific impact of A\u03b2, with dynamic network alterations present in humans but not in A\u03b2 mouse models, suggesting additional non-A\u03b2-driven influences on dynamic functional connectivity in preclinical AD.<\/jats:p>","DOI":"10.64898\/2026.04.26.720907","type":"posted-content","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:12:38Z","timestamp":1777511558000},"source":"Crossref","is-referenced-by-count":0,"title":["Dissociable, species-specific impact of A\u03b2 on static and dynamic functional connectomes"],"prefix":"10.64898","author":[{"given":"Matteo M","family":"Grudny","sequence":"first","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-8078","authenticated-orcid":false,"given":"Thomas J","family":"Murdy","sequence":"additional","affiliation":[{"name":"Tufts University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D","family":"Simon","sequence":"additional","affiliation":[{"name":"University of California San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Vo","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Burns","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon G","family":"Lamb","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0816","authenticated-orcid":false,"given":"Catherine C","family":"Kaczorowski","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramita","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-4163","authenticated-orcid":false,"given":"Marcelo","family":"Febo","sequence":"additional","affiliation":[{"name":"University of Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.04.26.720907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:35:22Z","timestamp":1778841322000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.04.26.720907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.64898\/2026.04.26.720907","relation":{},"subject":[],"published":{"date-parts":[[2026,4,29]]},"subtype":"preprint"}}