{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:12:31Z","timestamp":1791400351594,"version":"4.3.3"},"posted":{"date-parts":[[2026,5,1]]},"group-title":"Neuroscience","reference-count":77,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["MJFF-021825"],"award-info":[{"award-number":["MJFF-021825"]}],"id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"crossref","award":["AG084497"],"award-info":[{"award-number":["AG084497"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT-159606"],"award-info":[{"award-number":["PJT-159606"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100018528","name":"Korean Neurological Association","doi-asserted-by":"crossref","award":["KNA-20-SK-13"],"award-info":[{"award-number":["KNA-20-SK-13"]}],"id":[{"id":"10.13039\/100018528","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["HI19C1330"],"award-info":[{"award-number":["HI19C1330"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>REM sleep behaviour disorder (RBD) is a prodromal manifestation of \u03b1-synucleinopathies such as Parkinson\u2019s disease. Evidence suggests that degeneration of REM sleep regulating neurons in the sublaterodorsal tegmental nucleus (SLD) could give rise to RBD, yet the specific cellular populations involved and their contribution to synucleinopathy progression remain unclear. Here, we investigated the role of defined SLD cell types in RBD pathogenesis. Using viral vector and fibril-based models of \u03b1-synucleinopathy, we show that \u03b1-synuclein pathology in SLD neurons triggers RBD in mice. Notably, glutamatergic SLD neurons are selectively vulnerable to synucleinopathy and the loss of these cells correlates with RBD severity. Propagation of synucleinopathy from the SLD to midbrain and forebrain structures leads to the emergence of neurological deficits associated with Parkinson\u2019s disease. These findings establish that SLD neurons are critical substrates for RBD and provide insight into the cellular mechanisms at play in the early stages of synucleinopathies.<\/jats:p>","DOI":"10.64898\/2026.04.28.719687","type":"posted-content","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:35:14Z","timestamp":1777671314000},"source":"Crossref","is-referenced-by-count":1,"title":["Cell vulnerability within the sublaterodorsal tegmental nucleus underlies REM sleep behaviour disorder in prodromal \u03b1-synucleinopathy"],"prefix":"10.64898","author":[{"given":"Russell","family":"Luke","sequence":"first","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-6271","authenticated-orcid":false,"given":"Han Soo","family":"Yoo","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease 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