{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:14:08Z","timestamp":1778066048118,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,1]]},"group-title":"Cancer Biology","reference-count":39,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["AIRC; I.G. 21541"],"award-info":[{"award-number":["AIRC; I.G. 21541"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  We previously reported that the murine lncRNA\n                  <jats:italic>Epr<\/jats:italic>\n                  is essential for maintaining colon mucosal integrity and permeability. Mice lacking\n                  <jats:italic>Epr<\/jats:italic>\n                  in the colon are more susceptible to colitis and tumor development. Additionally, we demonstrated that human\n                  <jats:italic>EPR<\/jats:italic>\n                  expression is reduced in ulcerative colitis and in a small cohort of colon adenocarcinoma patients. Here, we present evidence that human and mouse\n                  <jats:italic>EPR<\/jats:italic>\n                  share several key physiological features: preferential binding to the KH1 domain of their interacting protein, KSRP; specific expression in canonical and immature goblet cells of the large intestine; and a functional role in intestinal goblet cell development. The correlation between\n                  <jats:italic>EPR<\/jats:italic>\n                  levels and survival in large cohorts of metastatic colon adenocarcinoma patients, together with the capacity of human\n                  <jats:italic>EPR<\/jats:italic>\n                  to inhibit cell proliferation and induce apoptosis in two distinct human colon adenocarcinoma cell lines, suggests that\n                  <jats:italic>EPR<\/jats:italic>\n                  may serve as both a valuable prognostic marker for goblet cell-derived adenocarcinomas and a potential therapeutic target.\n                <\/jats:p>","DOI":"10.64898\/2026.04.28.719975","type":"posted-content","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:55:15Z","timestamp":1777665315000},"source":"Crossref","is-referenced-by-count":0,"title":["Novel role of the lncRNA EPR as oncosuppressor in intestinal cancer"],"prefix":"10.64898","author":[{"given":"N","family":"Shim","sequence":"first","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"},{"name":"University City High School, San Diego, CA 92122, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-4999","authenticated-orcid":false,"given":"M","family":"Rossi","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6534-1874","authenticated-orcid":false,"given":"M","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"},{"name":"Graduate 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Policlinico San Martino, Genova, 16132, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-0095","authenticated-orcid":false,"given":"PL","family":"Puri","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-0611","authenticated-orcid":false,"given":"R","family":"Gherzi","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"},{"name":"IRCCS Ospedale Policlinico San Martino, Genova, 16132, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-9968","authenticated-orcid":false,"given":"L","family":"Caputo","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026050603301148000_2026.04.28.719975v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-024-07487-W"},{"key":"2026050603301148000_2026.04.28.719975v1.2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01126-1"},{"key":"2026050603301148000_2026.04.28.719975v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.32"},{"key":"2026050603301148000_2026.04.28.719975v1.4","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1093\/nar\/gkad257","article-title":"LncRNA EPR regulates intestinal mucus production and protects against 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