{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:10:34Z","timestamp":1789668634347,"version":"4.0.1"},"posted":{"date-parts":[[2026,5,1]]},"group-title":"Neuroscience","reference-count":0,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["549186835"],"award-info":[{"award-number":["549186835"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,17]]},"abstract":"<jats:p>The human brain is organized into interacting functional systems. Their underlying neurobiological mechanisms remain difficult to study in vivo. Here, we adopt a topological framework to quantify the association between neurobiology and brain functional connectivity derived from both resting-state fMRI and MEG. Across six healthy adult cohorts (n = 19-112), regional variation in fMRI connectivity robustly aligns with the distribution of neurotransmitter receptors and transporters. These patterns are present in every single subject, replicate across all cohorts, and are mirrored in MEG. Most prominently, noradrenergic modulation of connectivity in a sensorimotor-insular network is consistently detected across individuals and linked to autonomic arousal. In pharmacological and clinical samples, associations are sensitive to neurotransmitter system manipulation and are altered in early psychosis, aligning with clinical symptomatology. These findings provide biological insight into typical and atypical functional organization of the human brain using a framework linking underlying neurobiology to the functional connectome (NEOFC).<\/jats:p>","DOI":"10.64898\/2026.04.28.721294","type":"posted-content","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:25:13Z","timestamp":1777631113000},"source":"Crossref","is-referenced-by-count":0,"title":["Linking human brain functional connectivity to underlying neurotransmitter systems"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-6073","authenticated-orcid":false,"given":"Leon D.","family":"Lotter","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Juelich; Juelich, Germany.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-5571","authenticated-orcid":false,"given":"Golia","family":"Shafiei","sequence":"additional","affiliation":[{"name":"Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-6076","authenticated-orcid":false,"given":"Daouia","family":"Larabi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Developmental Neuropsychology, University of Groningen; Groningen, the Netherlands.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-3215","authenticated-orcid":false,"given":"Abhay","family":"Koushik","sequence":"additional","affiliation":[{"name":"Max Planck School of Cognition; Stephanstr. 1A, Leipzig, Germany.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-8222","authenticated-orcid":false,"given":"Ottavia","family":"Dipasquale","sequence":"additional","affiliation":[{"name":"Olea Medical; La Ciotat, France.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitul","family":"Mehta","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology, and Neuroscience, King's College London; London, UK.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Cercignani","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University; Cardiff, UK.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Sethi","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King's College London; London, UK.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9584-3769","authenticated-orcid":false,"given":"Neil","family":"Harrison","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University; Cardiff, UK.;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160tefan","family":"Holiga","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. 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