{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:54:05Z","timestamp":1787032445850,"version":"build-2736575974"},"posted":{"date-parts":[[2026,5,4]]},"group-title":"Immunology","reference-count":123,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["1T32GM136534"],"award-info":[{"award-number":["1T32GM136534"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI158624"],"award-info":[{"award-number":["R01AI158624"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R03AI190880"],"award-info":[{"award-number":["R03AI190880"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R21AI171921"],"award-info":[{"award-number":["R21AI171921"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["GRFP DGE-214004"],"award-info":[{"award-number":["GRFP DGE-214004"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/00hasdx88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The intestinal epithelium harbors a large population of microbiota-dependent CD8\u03b1\u03b2\n                  <jats:sup>+<\/jats:sup>\n                  T cells whose antigen specificity and regulation are ill-defined. By identifying MHCIa-restricted TCRs and generating tetramers against the gut commensal Segmented Filamentous Bacteria, we demonstrate that a single commensal species drives a clonally expanded, antigen-specific CD8\u03b1\u03b2\n                  <jats:sup>+<\/jats:sup>\n                  T cell within the intraepithelial lymphocyte compartment. Mechanistically, the intestinal epithelium coordinates coincident signals governing this population: peptide:MHC-dependent TCR engagement drives pIEL accumulation, while \u03b1v\u03b26-mediated TGF\u03b2 activation restraints effector cell differentiation. Perturbation of epithelial cell-mediated TGF\u03b2 activation diverts commensal-specific CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells toward inflammatory differentiation states transcriptionally convergent with those observed in ulcerative colitis. The intestinal epithelium thus functions as a dual-signal organizer of commensal-specific CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cell responses, coupling differentiation to restraint through spatially coincident molecular cues.\n                <\/jats:p>","DOI":"10.64898\/2026.04.29.720676","type":"posted-content","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:45:22Z","timestamp":1777913122000},"source":"Crossref","is-referenced-by-count":1,"title":["Coincident epithelial signals restrain commensal-specific CD8\u03b1\u03b2\n                  <sup>+<\/sup>\n                  T cells in the intestine"],"prefix":"10.64898","author":[{"given":"Tayla M.","family":"Olsen","sequence":"first","affiliation":[{"name":"Gut Immunity Research Program, Benaroya Research Institute, Seattle, WA, USA"},{"name":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA, USA"},{"name":"Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Dufort","sequence":"additional","affiliation":[{"name":"Center for Systems Immunology, Benaroya Research Institute, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheenam","family":"Verma","sequence":"additional","affiliation":[{"name":"Gut Immunity Research Program, Benaroya Research Institute, Seattle, WA, USA"},{"name":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Krishna Kanth","family":"Makani","sequence":"additional","affiliation":[{"name":"Center for Systems Immunology and the Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cameron","sequence":"additional","affiliation":[{"name":"Center for Systems Immunology and the Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addison R.","family":"Gralen","sequence":"additional","affiliation":[{"name":"Gut Immunity Research Program, Benaroya Research Institute, Seattle, WA, USA"},{"name":"Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Immunology, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Molecular Medicine, 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