{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:15:49Z","timestamp":1785428149133,"version":"3.56.0"},"posted":{"date-parts":[[2026,5,1]]},"group-title":"Genomics","reference-count":33,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"award":["U01AT012984"],"award-info":[{"award-number":["U01AT012984"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Mounting evidence implicates herpesvirus reactivation in the etiology of Alzheimer\u2019s disease, yet we lack a refined molecular characterization of pathogenesis in neurodegeneration. Here, we mine over 10 petabytes of human sequencing data for viral transcripts, identifying recurrent herpes simplex virus 1 (HSV-1) reactivation in healthy but not pathological post-mortem human brain tissue. Integrative single-nucleus analyses resolve direct evidence of HSV-1 expression in RORB+ glutamatergic neurons, implicating viral reactivation in a neuronal population progressively lost during dementia.<\/jats:p>","DOI":"10.64898\/2026.04.29.721769","type":"posted-content","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:10:30Z","timestamp":1777680630000},"source":"Crossref","is-referenced-by-count":0,"title":["Resolving human neuronal herpesvirus reactivation via petabase-scale association studies"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-3534","authenticated-orcid":false,"given":"Jacob C.","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA"},{"name":"Jan and Dan Duncan Neurological Research Institute, Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4315-6262","authenticated-orcid":false,"given":"Artem","family":"Babaian","sequence":"additional","affiliation":[{"name":"The Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-0813","authenticated-orcid":false,"given":"Ryan S.","family":"Dhindsa","sequence":"additional","affiliation":[{"name":"Jan and Dan Duncan Neurological Research Institute, Texas Children\u2019s Hospital, Houston, TX, USA"},{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-4807","authenticated-orcid":false,"given":"Caleb A.","family":"Lareau","sequence":"additional","affiliation":[{"name":"Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026050517251657000_2026.04.29.721769v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"2026050517251657000_2026.04.29.721769v1.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm6131"},{"key":"2026050517251657000_2026.04.29.721769v1.3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/jcm8050651","article-title":"Vascular dysfunction in Alzheimer\u2019s disease: A prelude to the pathological process or a consequence of it?","volume":"8","year":"2019","journal-title":"J. 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