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Here, using the pristane-induced PH model, we identify interleukin-2-inducible T cell kinase (ITK) as a critical regulator of autoimmune lung injury. ITK deficiency (Itk\u207b\/\u207b) conferred near-complete protection from PH and associated multiorgan injury, accompanied by reduced proinflammatory monocytes and neutrophils and increased Foxp3\u207a regulatory T cells (Tregs). Adoptive transfer of Itk\u207b\/\u207b Tregs protected wild-type recipients from PH and suppressed systemic proinflammatory cytokines, identifying Tregs as key mediators of tissue protection. Mechanistically, lung Itk\u207b\/\u207bTregs exhibited increased amphiregulin, a mediator of tissue repair. Transcriptomic profiling further showed that ITK loss reprogrammed Tregs toward a metabolically and functionally enhanced state, with enrichment of oxidative phosphorylation, mTORC1 and STAT5 signaling, and tissue-repair programs. These findings establish ITK as a regulator of the balance between pulmonary injury and reparative immunity and support targeting the ITK axis in severe inflammatory lung disease.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:list list-type=\"bullet\">\n                    <jats:list-item>\n                      <jats:p>ITK deficiency protects against pristane-induced pulmonary hemorrhage (PH)<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Loss of ITK expands \u201csuper-fit\u201d canonical and non-canonical Tregs<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>ITK-deficient Tregs from lungs exhibit enriched Amphiregulin production<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>ITK-deficient Tregs exhibit enriched mTORC1, OXPHOS, and IL-10 production<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>Transfer of ITK-deficient Tregs rescues established PH and reverses proteinuria<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:p>ITK uncouples pathogenic inflammation from reparative tissue immunity<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.01.722312","type":"posted-content","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:50:15Z","timestamp":1778104215000},"source":"Crossref","is-referenced-by-count":0,"title":["ITK deficiency protects against autoimmune pulmonary hemorrhage by promoting Amphiregulin-producing regulatory T cells"],"prefix":"10.64898","author":[{"given":"Mohammad Saddam","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mobeen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim H.","family":"Topkaya","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Medical Imaging, Nanchang Medical College, Nanchang, Jiangxi, Public Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanne","family":"Trevail","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-4814","authenticated-orcid":false,"given":"Mobin","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026101218351160000_2026.05.01.722312v3.1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339700600506"},{"key":"2026101218351160000_2026.05.01.722312v3.2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320903798"},{"key":"2026101218351160000_2026.05.01.722312v3.3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/CPM.0000000000000271","article-title":"Systemic lupus erythematosus-associated diffuse alveolar hemorrhage: A case report and review of the literature","volume":"25","year":"2018","journal-title":"Clin Pulm Med"},{"key":"2026101218351160000_2026.05.01.722312v3.4","doi-asserted-by":"crossref","unstructured":"Ramaswami, A. , et al. 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