{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:10:21Z","timestamp":1779275421098,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,4]]},"group-title":"Neuroscience","reference-count":67,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>The hippocampus is a central hub of human memory and cognition and is closely associated with brain disorders. Studies have shown that it exhibits complex structural variation across the lifespan, yet the details of hippocampal morphology changes remain poorly understood. Here, we establish norms over the hippocampal geometry that resolve lamellar morphology and map lifespan trajectories across more than 27,000 individuals from 158 scanning sites. Hippocampal geometry shows spatially non-uniform developmental and ageing patterns across the lifespan, with lamellar thickness, width and length following dissociable trajectories. Across multiple brain disorders, this representation reveals localized and heterogeneous alterations beyond conventional subfield-level summaries, and uncovers a dichotomy in disease-associated patterns, with neurodegenerative conditions and schizophrenia showing predominant atrophy, whereas some other disorders exhibit focal or regionally selective hypertrophy. Transfer to a longitudinal Alzheimer\u2019s Disease Neuroimaging Initiative cohort further supports out-of-sample generalization of our approach and enables individual-level tracking and conversion risk stratification. Overall, this work establishes a population-scale geometric reference for the hippocampus, extends normative brain mapping from coarse regional phenotypes to anatomically organized subcortical structure, and enables anatomically grounded characterization of disease-related alterations and individual-level deviation mapping, providing a principled basis for understanding and stratifying brain disorders across the lifespan in health and disease.<\/jats:p>","DOI":"10.64898\/2026.05.02.722431","type":"posted-content","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:10:14Z","timestamp":1777893014000},"source":"Crossref","is-referenced-by-count":0,"title":["Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan"],"prefix":"10.64898","author":[{"given":"Yanwu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Max-Planck Institute for Intelligent Systems, T\u00fcbingen, Germany"},{"name":"German Center for Mental Health (DZPG), partner site T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"German Center for Mental Health (DZPG), partner site T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guinan","family":"Su","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Intelligent Systems, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Dinga","sequence":"additional","affiliation":[{"name":"Department of Cognitive Science and Artificial Intelligence, Tilburg University, Tilburg, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Selvaggi","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"High Performance and Cloud Computing Division, Zentrum f\u00fcr Datenverarbeitung, University of T\u00fcbingen, 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