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The gut serves as its primary reservoir, yet factors governing colonization and pathogenic potential remain poorly defined. Here, we identify immunoglobulin A (IgA) as a key regulator of\n                  <jats:italic>C. glabrata<\/jats:italic>\n                  within the intestinal microbiome. We found that\n                  <jats:italic>C. glabrata<\/jats:italic>\n                  induces an IgA response in a strain-specific manner. Comparative transcriptional and proteomic analyses of IgA-inducing and non-inducing strains identified a putative adhesin, Awp11, whose expression correlated with IgA induction. Awp11 is directly targeted by IgA and is required for inducing\n                  <jats:italic>C. glabrata<\/jats:italic>\n                  -specific IgA and Th17 responses in vivo. Functionally, Awp11 promotes colonization of a complex intestinal microbiome, and intestinal IgA limits this advantage. In most strains,\n                  <jats:italic>AWP11<\/jats:italic>\n                  transcription is dynamic and limited by IgA in the gut. This identifies Awp11 as a key determinant of strain-dependent immunogenicity and gut colonization that\n                  <jats:italic>C. glabrata<\/jats:italic>\n                  may dynamically regulate to balance colonization and immune evasion.\n                <\/jats:p>","DOI":"10.64898\/2026.05.04.722752","type":"posted-content","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:10:38Z","timestamp":1778217038000},"source":"Crossref","is-referenced-by-count":1,"title":["A\n                  <i>Candida glabrata<\/i>\n                  adhesin-like effector drives fitness and immunogenicity in the gut"],"prefix":"10.64898","author":[{"given":"Owen","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-7545","authenticated-orcid":false,"given":"Mathieu","family":"H\u00e9nault","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne E.","family":"Haskins","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Trujillo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Heasley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-2836","authenticated-orcid":false,"given":"Kyla S.","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026050914350669000_2026.05.04.722752v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"2026050914350669000_2026.05.04.722752v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.08.016"},{"key":"2026050914350669000_2026.05.04.722752v1.3","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2026050914350669000_2026.05.04.722752v1.4","doi-asserted-by":"crossref","unstructured":"Gold JAW , Benedict K , Lyman M , Toda M , Little JS , Ostrosky-Zeichner L . 2026. 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