{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:10:22Z","timestamp":1778296222856,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,6]]},"group-title":"Neurology","reference-count":52,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We investigated associations of neighborhood disadvantage with Alzheimer\u2019s Disease (AD)-related outcomes by biological and social factors in at-risk older adults.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>1,880 U.S. POINTER participants with Area Deprivation Index (ADI) and cognition (PACC) were included. 868 had amyloid, tau PET, white matter hyperintensities (WMH), and\/or gray matter volumes. We conducted exploratory, linear models testing ADI interactions with sex, race and ethnicity, and APOE \u03b54, adjusting for age and education.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>\u201cWhite\/European American\u201d, \u201cHispanic\/Latinx\/Spanish\u201d and \u201cOthers\u201d showed lower cognitive scores with higher ADI, while \u201cWhite\/European American\u201d showed the highest cognitive scores across ADI levels. APOE \u03b54 carriers from high-ADI areas showed higher WMH and tau, and \u201cHispanic\/Latinx\/Spanish\u201d from more deprived areas showed higher WMH. Females from moderate-ADI areas showed higher tau. Amyloid burden was higher in APOE \u03b54 carriers from low-ADI areas.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Differential associations of ADI with AD-related outcomes across biological and social factors may reflect systemic health disparities and study design.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.05.26352370","type":"posted-content","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:55:14Z","timestamp":1778086514000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of neighborhood deprivation with Alzheimer\u2019s Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE \u03b54 status"],"prefix":"10.64898","author":[{"given":"Pablo","family":"Aguilar-Dominguez","sequence":"first","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain"},{"name":"University of Pompeu Fabra (UPF), Barcelona, Spain"},{"name":"Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen-Maria","family":"Colceriu","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain"},{"name":"University of Pompeu Fabra (UPF), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Monroe","family":"Holland","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-5420","authenticated-orcid":false,"given":"Samuel N","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine, Winston-Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Masdeu","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lycia Tramujas","family":"Vasconcellos Neumann","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Association, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather M","family":"Snyder","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Association, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D","family":"Baker","sequence":"additional","affiliation":[{"name":"Houston Methodist Research Institute, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Bejanin","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Landau","sequence":"additional","affiliation":[{"name":"University of California, Berkeley, Berkeley, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eider","family":"Arenaza-Urquijo","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026050819300956000_2026.05.05.26352370v1.1","unstructured":"Alzheimer\u2019s Disease International, World Alzheimer Report 2015 The global impact of dementia. 2015. 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