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While improvements in biomaterials have been made, including granular hydrogels and ECM-derived scaffolds, current biomaterials lack intentional design choices for effective translation, including regulatory considerations, practical extrusion delivery, and biomimetic characteristics. Here, we develop and characterize a library of granular ECM (gECM) biomaterials for five key tissues (cartilage, bone, skin, liver, and kidney), in which ECM particles are densely packed within a hyaluronic acid hydrogel. We optimize tissue processing methods that preserve proteomic content and structure while also aligning with scale-up manufacturing and regulatory guidelines. We show that gECM hydrogels can be molded, extruded, and 3D-printed while retaining their shape, and they stabilize at physiological temperature and pH. Lastly, we demonstrate that bulk gECM mechanics are driven by tissue type, and gECM hydrogels support viability, proliferation, and tissue-specific cellular activity. Together, these findings establish gECM hydrogels as a translational and biomimetic platform for clinical tissue repair and complex\n                  <jats:italic>in vitro<\/jats:italic>\n                  models.\n                <\/jats:p>","DOI":"10.64898\/2026.05.06.723348","type":"posted-content","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:35:16Z","timestamp":1778538916000},"source":"Crossref","is-referenced-by-count":1,"title":["Granular Extracellular Matrix (gECM) Hydrogels Enable Distinct Composition and Mechanics Across Tissue Types for Translation"],"prefix":"10.64898","author":[{"given":"Juliet O.","family":"Heye","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Colorado Boulder; Boulder, CO USA"},{"name":"Biomedical Engineering Program, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon A.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Colorado Boulder; Boulder, CO USA"},{"name":"Biomedical Engineering Program, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem M.","family":"Visal","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Colorado Boulder; Boulder, CO USA"},{"name":"Materials Science & Engineering Program, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith O.","family":"Olulana","sequence":"additional","affiliation":[{"name":"Biological and Chemical Engineering, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Colorado Boulder; 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Boulder, CO USA"},{"name":"Biomedical Engineering Program, University of Colorado Boulder; Boulder, CO USA"},{"name":"BioFrontiers Institute, University of Colorado Boulder; Boulder, CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026051313550822000_2026.05.06.723348v1.1","unstructured":"[1] 3D Bioprinting Market to Set Astonishing Growth (CAGR of 21.3%) n.d. https:\/\/www.openpr.com\/news\/1721502\/3d-bioprinting-market-to-set-astonishing-growth-cagr-of-21-3-by-key-players-biobots-cellink-gesim-poietis.html (accessed December 29, 2025)."},{"key":"2026051313550822000_2026.05.06.723348v1.2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/AC584C"},{"key":"2026051313550822000_2026.05.06.723348v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/ASJ\/SJAD173"},{"key":"2026051313550822000_2026.05.06.723348v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201200062"},{"key":"2026051313550822000_2026.05.06.723348v1.5","unstructured":"[5] Medical Devices Containing Materials Derived from Animal Sources (Except for In Vitro Diagnostic Devices) Guidance for Industry and Food and Drug Administration Staff Preface Public Comment n.d."},{"key":"2026051313550822000_2026.05.06.723348v1.6","unstructured":"[6] Fda, Cber. 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