{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:07:38Z","timestamp":1778954858729,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,13]]},"group-title":"Neuroscience","reference-count":35,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,12]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Impairment of brain waste removal contributes to Alzheimer\u2019s disease etiology and progression. Although hypertension is a risk factor for dementia, little is known about how it affects measures of clearance in human brain.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional (n=159) and longitudinal (n=94) analysis of the relationship between blood pressure (BP) and brain clearance. The estimate of brain clearance was measured using positron emission tomography (PET) as the rate of radiotracer (MK-6240) efflux from the lateral ventricles in the 10\u201330-minute window after tracer injection. We also examined cerebral blood flow, PET-derived tau deposition in the medial temporal lobe, cognition and plasma biomarkers of neurodegeneration. At baseline we compared participants with (n=88) and without (n=71) hypertension. For longitudinal analyses we defined two groups based on systolic BP trajectories from baseline to follow-up: as long-term controlled (n=76) or uncontrolled BP (n=18).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At baseline, subjects with hypertension had lower ventricular clearance than normotensive controls (Cohen\u2019s d=0.53, p=0.001). Over the course of the observation period (median 1.85 years) subjects in the uncontrolled BP group experienced a steeper reduction in clearance rates (\u03b2=-5.88) than subjects in the controlled BP group (\u03b2=-0.81, interaction p=0.039).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study suggests that hypertension impairs brain clearance of fluids.<\/jats:p>\n                <\/jats:sec>","DOI":"10.64898\/2026.05.07.723657","type":"posted-content","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:35:16Z","timestamp":1778697316000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertension is related to a slower radiotracer removal from lateral ventricles"],"prefix":"10.64898","author":[{"given":"Katarzyna","family":"Olejniczak-Gniadek","sequence":"first","affiliation":[{"name":"Brain Health Imaging Institute, Department of Radiology, Weill 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