{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:15:46Z","timestamp":1778944546229,"version":"3.51.4"},"posted":{"date-parts":[[2026,5,13]]},"group-title":"Bioengineering","reference-count":25,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH\/NIDCD"},{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["PJT-189955"],"award-info":[{"award-number":["PJT-189955"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,5,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Quantifying the diagnostic dispersion of inferred parameter distributions is a challenge in uncertainty-aware modeling. Scalar summaries such as credible interval width are topology-blind; fundamentally different posterior morphologies can yield identical scores, obscuring whether a parameter is precisely estimated or constrained to a range. We propose a Composite Certainty Framework that addresses this metric degeneracy by aggregating five complementary uncertainty metrics including interquartile range, standard deviation, full width at half maximum, Shannon entropy, and mass width. These metrics are aggregated through non-parametric Borda rank voting into a single, unitless consensus certainty score. Applied to a simulation-based inference pipeline for a finite-element model of the human middle ear tuned to cadaveric acoustic measurements, the framework reveals parameter-specific identifiability profiles invisible to any individual metric. It produces two actionable clinical thresholds: (1) the maximum tolerable measurement noise for reliable parameter recovery, and (2) the minimum simulation budget for posterior convergence. We demonstrated that no single metric captures all aspects of posterior dispersion, as spread-based metrics and entropy diverge systematically for clinically critical parameters, whereas their aggregation produces a consensus reflecting genuine diagnostic certainty. The framework is generalizable to any model-based diagnostic pipeline where posterior distribution not merely its coverage, but determines clinical certainty.<\/jats:p>","DOI":"10.64898\/2026.05.09.724027","type":"posted-content","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:25:22Z","timestamp":1778700322000},"source":"Crossref","is-referenced-by-count":0,"title":["Composite Certainty: Addressing Metric Degeneracy in Parameter Inference for Model-Based Diagnostics"],"prefix":"10.64898","author":[{"given":"Amruta","family":"Koshe","sequence":"first","affiliation":[{"name":"iKinesia Inc., Montreal, QC, J4W 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-9952","authenticated-orcid":false,"given":"Ehsan","family":"Sobhani Tehrani","sequence":"additional","affiliation":[{"name":"iKinesia Inc., Montreal, QC, J4W 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-158X","authenticated-orcid":false,"given":"Kian","family":"Jalaleddini","sequence":"additional","affiliation":[{"name":"iKinesia Inc., Montreal, QC, J4W 1Y4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-5263","authenticated-orcid":false,"given":"Hamid","family":"Motallebzadeh","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, California State University, Sacramento, CA, 95819, USA"},{"name":"Department of BioMedical Engineering, McGill University, QC, H3A 0G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026051607500779000_2026.05.09.724027v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2021.05.008"},{"key":"2026051607500779000_2026.05.09.724027v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-018-0004-1"},{"key":"2026051607500779000_2026.05.09.724027v1.3","doi-asserted-by":"publisher","DOI":"10.1002\/047174882X"},{"key":"2026051607500779000_2026.05.09.724027v1.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912789117"},{"key":"2026051607500779000_2026.05.09.724027v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx124"},{"key":"2026051607500779000_2026.05.09.724027v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.strusafe.2008.06.020"},{"key":"2026051607500779000_2026.05.09.724027v1.7","doi-asserted-by":"publisher","DOI":"10.1145\/371920.372165"},{"key":"2026051607500779000_2026.05.09.724027v1.8","first-page":"191","article-title":"A review of challenges and opportunities in machine learning for health","volume":"2020","year":"2020","journal-title":"AMIA Summits on Translational Science Proceedings"},{"key":"2026051607500779000_2026.05.09.724027v1.9","unstructured":"Hermans, J. , Delaunoy, A. , Rozet, F. , Wehenkel, A. , Begy, V. , & Louppe, G. 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